Research Unit, Galdakao-Usansolo Hospital, Galdakao, Spain.
Health Services Research on Chronic Diseases Network-REDISSEC, Galdakao, Spain.
Eur Eat Disord Rev. 2019 Nov;27(6):603-613. doi: 10.1002/erv.2677. Epub 2019 Apr 24.
The goal of this study is to identify potential factors that have a significant effect on anxiety and depression of patients with eating disorders (ED) using the beta-binomial regression (BBR) approach on a broad sample of patients.
This cross-sectional study involved 520 ED patients. The effect of sociodemographics, core symptoms, general health outcomes, and medical comorbidities in anxiety and depression were analysed jointly using the beta-binomial mixed-effects model.
Two hundred fifty-five (49.4%) patients had anorexia nervosa, 173 (33.3%) patients had bulimia nervosa, and 92 (17.7%) had ED not otherwise specified. A high level of anxiety was associated, among other variables, with having a restrictive ED subtype as compared with purgative and binge ED subtypes (β = -0.2, p < 0.001, OR = 0.82 and β = -0.16, p < 0.03, OR = 0.85, respectively), with having a high level of ED symptomatology or with living not alone (β = -0.23, p = 0.002, OR = 0.80). A high level of depression was associated, among other variables, with older age (β = 0.74, p < 0.001, OR = 2.1).
The results of our study suggest that depressive and anxiety symptoms are related to ED symptoms, health status, ED subtype, medical comorbitidy, and educational level. In addition, another interesting finding is the inverse association between symptomatology of anxiety and living alone. Finally, BBR may be a useful approach in interpreting patient-reported outcome as odds.
本研究旨在使用贝塔二项式回归（BBR）方法对广泛的患者样本，确定对饮食障碍（ED）患者焦虑和抑郁有显著影响的潜在因素。
这是一项横断面研究，共纳入 520 名 ED 患者。使用贝塔二项式混合效应模型联合分析了社会人口统计学、核心症状、一般健康结果和合并症对焦虑和抑郁的影响。
255 名（49.4%）患者患有神经性厌食症，173 名（33.3%）患者患有神经性贪食症，92 名（17.7%）患者患有未特定的 ED。与其他变量相比，高焦虑水平与限制型 ED 亚型有关，而与泻食型和暴食型 ED 亚型有关（β=-0.2，p<0.001，OR=0.82 和 β=-0.16，p<0.03，OR=0.85），与 ED 症状严重程度高或独居（β=-0.23，p=0.002，OR=0.80）有关。高抑郁水平与其他变量有关，与年龄较大（β=0.74，p<0.001，OR=2.1）有关。
本研究结果表明，抑郁和焦虑症状与 ED 症状、健康状况、ED 亚型、合并症和教育程度有关。此外，另一个有趣的发现是焦虑症状与独居之间存在负相关。最后，BBR 可能是一种有用的方法，可以将患者报告的结果解释为优势比。
