Toda Yasunori, Tanaka Shoya, Gomyou Shuto, Kikuchi Ayaka, Suga Hiroyuki
Department of Materials Chemistry, Faculty of Engineering, Shinshu University, 4-17-1 Wakasato, Nagano 380-8553, Japan.
Chem Commun (Camb). 2019 May 16;55(41):5761-5764. doi: 10.1039/c9cc01983a.
Preparation of 4-hydroxymethyl-substituted oxazolidinones including optically active ones, in which tetraarylphosphonium salts catalyze the reaction of glycidol with isocyanates effectively, is described. The neutral catalysis facilitates glycidol addition to isocyanates followed by intramolecular cyclization. Mechanistic studies suggest that hydrogen-bonding interactions with the catalyst play an important role in the reaction progress.
描述了4-羟甲基取代的恶唑烷酮的制备方法，包括旋光性的恶唑烷酮，其中四芳基鏻盐可有效催化缩水甘油与异氰酸酯的反应。中性催化作用有利于缩水甘油加成到异氰酸酯上，随后进行分子内环化。机理研究表明，与催化剂的氢键相互作用在反应过程中起重要作用。
