Toyofuku Masanori
a Faculty of Life and Environmental Sciences, University of Tsukuba , Tsukuba , Japan.
b Microbiology Research Center for Sustainability (MiCS), University of Tsukuba , Tsukuba , Japan.
Biosci Biotechnol Biochem. 2019 Sep;83(9):1599-1605. doi: 10.1080/09168451.2019.1608809. Epub 2019 Apr 25.
Bacteria can communicate through diffusible signaling molecules that are perceived by cognate receptors. It is now well established that bacterial communication regulates hundreds of genes. Hydrophobic molecules which do not diffuse in aqueous environments alone have been identified in bacterial communication, that raised the question on how these molecules are transported between cells and trigger gene expressions. Recent studies show that these hydrophobic signaling molecules, including a long-chain -acyl homoserine lactone signal produced in , are carried by membrane vesicles (MVs). MVs were thought to be formed only through the blebbing of the cell membrane, but new findings in and revealed that different types of MVs can be formed through explosive cell lysis or bubbling cell death, which findings have certain implications on our view of bacterial interactions.
细菌可以通过可扩散的信号分子进行通讯，这些信号分子可被同源受体识别。现在已经充分证实，细菌通讯可调控数百个基因。在细菌通讯中已鉴定出不能单独在水性环境中扩散的疏水分子，这就引发了关于这些分子如何在细胞间运输并触发基因表达的问题。最近的研究表明，这些疏水性信号分子，包括在[具体来源未提及]中产生的长链酰基高丝氨酸内酯信号，是由膜泡（MVs）携带的。膜泡曾被认为仅通过细胞膜的起泡形成，但[具体文献1]和[具体文献2]中的新发现表明，不同类型的膜泡可通过爆炸性细胞裂解或气泡状细胞死亡形成，这些发现对我们对细菌相互作用的看法有一定影响。
