Waisman Center, University of Wisconsin, Madison, WI, USA.
Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.
J Cell Biol. 2024 Jul 1;223(7). doi: 10.1083/jcb.202310134. Epub 2024 May 15.
Bacteria, omnipresent in our environment and coexisting within our body, exert dual beneficial and pathogenic influences. These microorganisms engage in intricate interactions with the human body, impacting both human health and disease. Simultaneously, certain organelles within our cells share an evolutionary relationship with bacteria, particularly mitochondria, best known for their energy production role and their dynamic interaction with each other and other organelles. In recent years, communication between bacteria and mitochondria has emerged as a new mechanism for regulating the host's physiology and pathology. In this review, we delve into the dynamic communications between bacteria and host mitochondria, shedding light on their collaborative regulation of host immune response, metabolism, aging, and longevity. Additionally, we discuss bacterial interactions with other organelles, including chloroplasts, lysosomes, and the endoplasmic reticulum (ER).
细菌在我们的环境中无处不在，与我们的身体共存，对我们的身体具有双重有益和致病的影响。这些微生物与人体进行着复杂的相互作用，影响着人类的健康和疾病。同时，我们细胞内的某些细胞器与细菌有着进化关系，特别是线粒体，线粒体以其能量产生作用及其与彼此和其他细胞器的动态相互作用而闻名。近年来，细菌和线粒体之间的通讯已经成为一种新的调节宿主生理和病理的机制。在这篇综述中，我们深入探讨了细菌和宿主线粒体之间的动态通讯，阐明了它们在调节宿主免疫反应、代谢、衰老和长寿方面的协同作用。此外，我们还讨论了细菌与其他细胞器（包括叶绿体、溶酶体和内质网）的相互作用。
