Wagnerová M, Znojemská S, Wagner V, Hrebacka J
Czech Med. 1986;9(4):210-7.
A cohort of 66 workers professionally exposed to vinylchloride (VC) in a plant producing polyvinylchloride was examined in years 1979 and 1985 by same methods. Significant changes of the levels of immunoglobulins (Ig), lysozyme and transferrin were not observed during the six years in the subgroup of smokers. Nevertheless a highly significant rise of alpha 2 macroglobulin (A2M) and ceruloplasmin (CPL) levels in this subgroup was stated. The levels of IgA and IgM significantly rose in the subgroup of ex-smokers, as well as highly significant increase of A2M was noted in this subgroup. The levels of IgG and A2M rose with highly significance in the subgroup of non-smokers; the CPL increase was only of weak significance. Many significant differences in means were assessed between subgroups of exposed workers and age matched control persons. No significant correlation between the levels of the tests and the time of exposure to VC was observed by regression analysis. In the discussion an opinion about possible premature aging of persons exposed to VC was brought forward.
1979年和1985年，采用相同方法对一家聚氯乙烯生产厂中66名职业性接触氯乙烯（VC）的工人进行了检查。在这六年中，吸烟者亚组的免疫球蛋白（Ig）、溶菌酶和转铁蛋白水平未观察到显著变化。然而，该亚组的α2巨球蛋白（A2M）和铜蓝蛋白（CPL）水平有高度显著升高。戒烟者亚组的IgA和IgM水平显著升高，该亚组的A2M也有高度显著增加。非吸烟者亚组的IgG和A2M水平有高度显著升高；CPL的升高仅具有微弱显著性。评估了接触工人亚组与年龄匹配的对照人员之间的许多均值显著差异。通过回归分析未观察到检测水平与接触VC时间之间的显著相关性。在讨论中，提出了关于接触VC人员可能过早衰老的观点。
