Bencko V, Wagner V, Wagnerová M, Bátora J, Hrebacka J
Postgraduate School of Medicine and Pharmacy, Prague, Czechoslovakia.
J Hyg Epidemiol Microbiol Immunol. 1988;32(4):375-84.
The immunobiochemical studies were conducted in a group of 98 production workers engaged in polyvinyl chloride manufacture from ethylene (group A workers) and in a group of 59 vinyl chloride workers from a chemical plant employing classic production technology from acetylene (group B workers). Both groups of workers were matched by age (group A workers: 37.7 +/- 8.66 years; group B workers: 34.9 +/- 11.2 years) and average exposure length (group A workers: 8.6 +/- 3.0 years; group B workers: 10.7 +/- 8.4 years). All workers were examined for the serum concentrations of immunoglobulins IgG, IgA and IgM and acute reactants lysozyme (LYS), transferrin (TRF), ceruloplasmin (CPL), alpha-l-antitrypsin (AlAT), alpha-2-macroglobulin (A2M) and orosomucoid (ORO). The statistical analysis included calculations of means, standard deviations and 95% confidence intervals. Differences in means were evaluated by t-test, differences in the distribution pattern of values by F-test. Abnormality of values was assessed by comparisons to normal values valid in Czechoslovakia. Group A worked in conditions meeting the MAC 10 mg VC.m-3 comparing with group B workers had elevated levels of IgG (P less than 0.005), IgA and IgM (P less than 0.001 both). Group B workers differed from group A workers by exhibiting significantly elevated levels of AlAT, and CPL. (P less than 0.001). The differences in the frequency of abnormal values between group A and group B worked in substantially less favourable hygienic conditions were significant for immunoglobulins elevated in group A and for ORO (P less than 0.01) and CPL (P less than 0.001) elevated in group B. The possible relationship of these immunobiochemical findings with the degree of vinyl chloride exposure are critically analyzed.
对一组98名从事由乙烯生产聚氯乙烯的生产工人（A组工人）和一组59名来自采用乙炔经典生产工艺的化工厂的氯乙烯工人（B组工人）进行了免疫生化研究。两组工人在年龄（A组工人：37.7±8.66岁；B组工人：34.9±11.2岁）和平均接触时长（A组工人：8.6±3.0年；B组工人：10.7±8.4年）方面进行了匹配。对所有工人检测了血清免疫球蛋白IgG、IgA和IgM以及急性反应物溶菌酶（LYS）、转铁蛋白（TRF）、铜蓝蛋白（CPL）、α-1抗胰蛋白酶（AlAT）、α-2巨球蛋白（A2M）和类粘蛋白（ORO）的浓度。统计分析包括均值、标准差和95%置信区间的计算。均值差异通过t检验评估，数值分布模式差异通过F检验评估。通过与捷克斯洛伐克有效的正常值比较来评估数值异常情况。A组工人的工作条件符合MAC 10 mg VC·m⁻³，与B组工人相比，其IgG水平升高（P＜0.005），IgA和IgM水平均升高（均P＜0.001）。B组工人与A组工人不同，其AlAT和CPL水平显著升高（P＜0.001）。A组和B组工作在卫生条件明显较差环境中的工人之间，A组升高的免疫球蛋白以及B组升高的ORO（P＜0.01）和CPL（P＜0.001）的异常值频率差异具有显著性。对这些免疫生化结果与氯乙烯接触程度之间可能的关系进行了批判性分析。
