Department of Ophthalmology, Kirikkale University Medical Faculty, Kirikkale, Turkey.
Reyhan Oğurel Eye Clinic, Kirikkale, Turkey.
Retina. 2020 Jun;40(6):1200-1206. doi: 10.1097/IAE.0000000000002535.
To study blood cobalt (Co) and chromium (Cr) levels in patients who have undergone total knee arthroplasty and their effect on the retinal nerve fiber layer and macular ganglion cell complex.
One hundred patients who had undergone total knee arthroplasty and 50 healthy individuals who had no implants were included in the study. The patients were separated into two groups based on how long ago the prosthesis had been implanted (Group 1: 1 to 5 years; Group 2: 5 to 10 years). After a complete ophthalmological examination, retinal nerve fiber layer and macular ganglion cell complex of the patients were evaluated with optical coherence tomography, performed on dilated pupils. To assess the metal ion levels of the patients, venous blood samples were drawn from each patient.
The mean age of the patients was 64.72 ± 6.26 years in Group 1, 67.80 ± 8.07 years in Group 2, and 63.42 ± 7.90 years in the control group. In the comparison of age and sex, there were no statistically significant differences between the groups and the control group. Co and Cr levels were statistically higher in Group 1 and Group 2 compared with the control group (P < 0.001). Mean retinal nerve fiber layer thicknesses and mean macular ganglion cell complex thicknesses in Group 1 and Group 2 were statistically lower than in the control group.
Levels of Co and Cr are higher in patients who undergone total knee arthroplasty than healthy subjects, and these higher levels were associated with changes in the retinal nerve fiber layer and macular ganglion cell complex.
研究全膝关节置换术后患者血液中的钴（Co）和铬（Cr）水平及其对视网膜神经纤维层和黄斑神经节细胞复合体的影响。
本研究纳入了 100 名接受全膝关节置换术的患者和 50 名无植入物的健康对照者。根据假体植入时间长短将患者分为两组（第 1 组：1-5 年；第 2 组：5-10 年）。在全面的眼科检查后，使用散瞳后光学相干断层扫描评估患者的视网膜神经纤维层和黄斑神经节细胞复合体。为评估患者的金属离子水平，从每位患者抽取静脉血样本。
第 1 组患者的平均年龄为 64.72 ± 6.26 岁，第 2 组为 67.80 ± 8.07 岁，对照组为 63.42 ± 7.90 岁。在年龄和性别比较中，各组与对照组之间无统计学差异。与对照组相比，第 1 组和第 2 组的 Co 和 Cr 水平明显更高（P < 0.001）。第 1 组和第 2 组的平均视网膜神经纤维层厚度和平均黄斑神经节细胞复合体厚度均明显低于对照组。
与健康受试者相比，接受全膝关节置换术的患者血液中的 Co 和 Cr 水平更高，这些更高的水平与视网膜神经纤维层和黄斑神经节细胞复合体的改变有关。
