Wescott Delainey L, Morash-Conway Jessica, Zwicker Alyson, Cumby Jill, Uher Rudolf, Rusak Benjamin
Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada.
Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Front Psychiatry. 2019 Apr 8;10:225. doi: 10.3389/fpsyt.2019.00225. eCollection 2019.
Sleep problems in childhood are an early predictor of mood disorders among individuals at high familial risk. However, the majority of the research has focused on sleep disturbances in already diagnosed individuals and has largely neglected investigating potential differences between weeknight and weekend sleep in high-risk offspring. This study examined sleep parameters in offspring of parents with major depressive disorder or bipolar disorder during both weeknights and weekends. We used actigraphy, sleep diaries, and questionnaires to measure several sleep characteristics in 73 offspring aged 4-19 years: 23 offspring of a parent with major depressive disorder, 22 offspring of a parent with bipolar disorder, and 28 control offspring. Offspring of parents with major depressive disorder slept, on average, 26 min more than control offspring on weeknights (95% confidence interval, 3 to 49 min, = 0.027). Offspring of parents with bipolar disorder slept, on average, 27 min more on weekends than on weeknights compared to controls, resulting in a significant family history × weekend interaction (95% confidence interval, 7 to 47 min, = 0.008). Sleep patterns in children and adolescents were related to the psychiatric diagnosis of their parent(s). Future follow-up of these results may clarify the relations between early sleep differences and the risk of developing mood disorders in individuals at high familial risk.
儿童期睡眠问题是高家族风险个体情绪障碍的早期预测指标。然而，大多数研究集中在已确诊个体的睡眠障碍上，很大程度上忽视了调查高风险后代工作日和周末睡眠的潜在差异。本研究调查了患有重度抑郁症或双相情感障碍的父母的后代在工作日和周末的睡眠参数。我们使用活动记录仪、睡眠日记和问卷来测量73名4至19岁后代的几种睡眠特征：23名父母患有重度抑郁症的后代、22名父母患有双相情感障碍的后代和28名对照后代。在工作日，父母患有重度抑郁症的后代平均比对照后代多睡26分钟（95%置信区间，3至49分钟，P = 0.027）。与对照组相比，父母患有双相情感障碍的后代在周末比在工作日平均多睡27分钟，导致显著的家族病史×周末交互作用（95%置信区间，7至47分钟，P = 0.008）。儿童和青少年的睡眠模式与其父母的精神疾病诊断有关。对这些结果的未来随访可能会阐明早期睡眠差异与高家族风险个体患情绪障碍风险之间的关系。
