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1
Plasma microfibrillar-associated protein 4 is not prognostic of emphysema progression but is associated with cardiovascular disease history and mortality in COPD patients.血浆微原纤维相关蛋白4对慢性阻塞性肺疾病（COPD）患者的肺气肿进展无预后价值，但与心血管疾病史及死亡率相关。
ERJ Open Res. 2019 Apr 15;5(2). doi: 10.1183/23120541.00021-2019. eCollection 2019 Apr.
2
A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD.一项大型肺部基因表达研究鉴定出纤连蛋白-5 是 COPD 组织修复中的一个新的参与者。
Thorax. 2015 Jan;70(1):21-32. doi: 10.1136/thoraxjnl-2014-205091. Epub 2014 Jul 2.
3
Microfibrillar-associated protein 4: a potential biomarker of chronic obstructive pulmonary disease.微原纤维相关蛋白4：慢性阻塞性肺疾病的一种潜在生物标志物。
Respir Med. 2014 Sep;108(9):1336-44. doi: 10.1016/j.rmed.2014.06.003. Epub 2014 Jun 20.
4
Integrated analysis of microfibrillar-associated proteins reveals MFAP4 as a novel biomarker in human cancers.微纤维相关蛋白的综合分析显示 MFAP4 是人类癌症的一种新型标志物。
Epigenomics. 2019 Jan;11(1):1635-1651. doi: 10.2217/epi-2018-0080. Epub 2018 Aug 9.
5
Association between microfibrillar-associated protein 4 (MFAP4) and micro- and macrovascular complications in long-term type 1 diabetes mellitus.微原纤维相关蛋白4（MFAP4）与长期1型糖尿病微血管和大血管并发症之间的关联
Acta Diabetol. 2017 Apr;54(4):367-372. doi: 10.1007/s00592-016-0953-y. Epub 2016 Dec 30.
6
Lung, Fat and Bone: Increased Adiponectin Associates with the Combination of Smoking-Related Lung Disease and Osteoporosis.肺、脂肪与骨骼：脂联素水平升高与吸烟相关肺部疾病和骨质疏松症的合并症有关。
Chronic Obstr Pulm Dis. 2018 Apr 1;5(2):134-143. doi: 10.15326/jcopdf.5.2.2016.0174.
7
Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease.在慢性阻塞性肺疾病患者中，动脉僵硬度与肺气肿严重程度独立相关。
Am J Respir Crit Care Med. 2007 Dec 15;176(12):1208-14. doi: 10.1164/rccm.200707-1080OC. Epub 2007 Sep 20.
8
Direct-acting antivirals-based therapy decreases hepatic fibrosis serum biomarker microfibrillar-associated protein 4 in hepatitis C patients.基于直接作用抗病毒药物的治疗可降低丙型肝炎患者肝纤维化血清生物标志物微纤维相关蛋白 4。
Clin Mol Hepatol. 2019 Mar;25(1):42-51. doi: 10.3350/cmh.2018.0029. Epub 2018 Nov 19.
9
Risk factors for lung cancer in COPD - results from the Bergen COPD cohort study.COPD 患者肺癌的风险因素 - 卑尔根 COPD 队列研究的结果。
Respir Med. 2019 Jun;152:81-88. doi: 10.1016/j.rmed.2019.04.019. Epub 2019 Apr 30.
10
Association of plasma adipokines with chronic obstructive pulmonary disease severity and progression.血浆脂肪因子与慢性阻塞性肺疾病严重程度及进展的关联
Ann Am Thorac Soc. 2015 Jul;12(7):1005-12. doi: 10.1513/AnnalsATS.201501-005OC.

引用本文的文献

1
Serum MFAP4, a novel potential biomarker for liver cirrhosis screening, correlates with transient elastography in NAFLD patients.血清MFAP4是一种用于肝硬化筛查的新型潜在生物标志物，与非酒精性脂肪性肝病（NAFLD）患者的瞬时弹性成像相关。
JGH Open. 2023 Feb 23;7(3):197-203. doi: 10.1002/jgh3.12873. eCollection 2023 Mar.

本文引用的文献

1
Cardiovascular disease and COPD: dangerous liaisons?心血管疾病与 COPD：危险的联姻？
Eur Respir Rev. 2018 Oct 3;27(149). doi: 10.1183/16000617.0057-2018. Print 2018 Sep 30.
2
Microfibrillar-associated protein 4 variation in symptomatic peripheral artery disease.微纤维相关蛋白 4 在有症状的外周动脉疾病中的变异。
J Transl Med. 2018 Jun 8;16(1):159. doi: 10.1186/s12967-018-1523-6.
3
Evaluation of the biomarker candidate MFAP4 for non-invasive assessment of hepatic fibrosis in hepatitis C patients.评估生物标志物候选物MFAP4用于丙型肝炎患者肝纤维化的无创评估。
J Transl Med. 2016 Jul 4;14(1):201. doi: 10.1186/s12967-016-0952-3.
4
MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis?MFAP4：肝脏和肺纤维化的候选生物标志物？
Sarcoidosis Vasc Diffuse Lung Dis. 2016 Mar 29;33(1):41-50.
5
Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD.循环中的脱氧异皮质醇水平不能预测肺气肿的进展，但与 COPD 患者的心血管风险和死亡率相关。
Eur Respir J. 2016 May;47(5):1365-73. doi: 10.1183/13993003.01824-2015. Epub 2016 Mar 23.
6
Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.微原纤维相关蛋白4（MFAP4）作为参与弹性纤维形成的原弹性蛋白和原纤维蛋白结合蛋白的特性分析
J Biol Chem. 2016 Jan 15;291(3):1103-14. doi: 10.1074/jbc.M115.681775. Epub 2015 Nov 24.
7
MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation.MFAP4促进血管平滑肌迁移、增殖并加速新生内膜形成。
Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):122-33. doi: 10.1161/ATVBAHA.115.306672. Epub 2015 Nov 12.
8
Microfibrillar-Associated Protein 4: A Potential Biomarker for Screening for Liver Fibrosis in a Mixed Patient Cohort.微原纤维相关蛋白4：混合患者队列中肝纤维化筛查的潜在生物标志物。
PLoS One. 2015 Oct 13;10(10):e0140418. doi: 10.1371/journal.pone.0140418. eCollection 2015.
9
Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma.微纤维相关蛋白 4 调节实验性哮喘中的气道平滑肌细胞表型。
Thorax. 2015 Sep;70(9):862-72. doi: 10.1136/thoraxjnl-2014-206609. Epub 2015 Jun 2.
10
Characterization of spontaneous air space enlargement in mice lacking microfibrillar-associated protein 4.缺乏微原纤维相关蛋白4的小鼠自发性气腔扩大的特征分析
Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1114-24. doi: 10.1152/ajplung.00351.2014. Epub 2015 Apr 10.

血浆微原纤维相关蛋白4对慢性阻塞性肺疾病（COPD）患者的肺气肿进展无预后价值，但与心血管疾病史及死亡率相关。

Plasma microfibrillar-associated protein 4 is not prognostic of emphysema progression but is associated with cardiovascular disease history and mortality in COPD patients.

作者信息

Johansson Sofie Lock, Wulf-Johansson Helle, Schlosser Anders, Titlestad Ingrid L, Miller Bruce, Tal-Singer Ruth, Holmskov Uffe, Vestbo Jørgen, Sørensen Grith Lykke

机构信息

Dept of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

Dept of Respiratory Medicine, Odense University Hospital, Odense, Denmark.

出版信息

ERJ Open Res. 2019 Apr 15;5(2). doi: 10.1183/23120541.00021-2019. eCollection 2019 Apr.

DOI:10.1183/23120541.00021-2019
PMID:31024964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6469069/
Abstract

http://ow.ly/6vnL30o8t1g.

摘要

http://ow.ly/6vnL30o8t1g. （此为网址，无法准确翻译为中文，保留原文即可）