IGF, University of Montpellier, CNRS, INSERM, Montpellier, France.
IGF, University of Montpellier, CNRS, INSERM, Montpellier, France.
Mol Cell Endocrinol. 2019 Jul 1;491:110397. doi: 10.1016/j.mce.2019.02.009. Epub 2019 Apr 24.
In this review article, we summarize the current knowledge on a large and diverse superfamily of seven-pass transmembrane proteins functionally independent from the GPCR superfamily. We include the newest research findings about their physiological roles and their mechanism of action. In particular, we concentrate on the structural basis for the newly discovered amide hydrolase activity, with a focus on adiponectin receptors for which structures are available. Finally, we discuss the remaining challenges in understanding the activation and signaling of these intramembrane proteins and suggest how regulation of the amide hydrolase activity may help in development of new therapeutic agents.
在这篇综述文章中，我们总结了目前关于一个大型、多样化的七跨膜蛋白超家族的知识，这些蛋白的功能与 G 蛋白偶联受体超家族无关。我们包括了关于它们生理作用和作用机制的最新研究结果。特别是，我们集中讨论了新发现的酰胺水解酶活性的结构基础，重点是可用结构的脂联素受体。最后，我们讨论了理解这些跨膜蛋白的激活和信号转导的剩余挑战，并提出了如何调节酰胺水解酶活性可能有助于开发新的治疗药物。
