Department of Cardiovascular Medicine, The First Hospital of China Medical University, 155 Nanjing Street, Heping, Shenyang, 110001, Liaoning, China.
BMC Psychiatry. 2019 Apr 26;19(1):125. doi: 10.1186/s12888-019-2114-7.
To explore the potential correlation between 10-year atherosclerotic cardiovascular disease (ASCVD) risk and depressive symptoms in a general population.
A cross-sectional study involving 11,956 permanent residents of Liaoning Province in China ≥35 years of age was conducted. Depressive symptoms were assessed with the Patient Health Questionnaire-9 (PHQ-9) while 10-year ASCVD risk was calculated using the tool suitable for China.
Males had significantly higher 10-year ASCVD risk than females (14.2 ± 10.7% vs. 9.3 ± 9.1%; P < 0.001) but lower PHQ-9 score (2.34 ± 3.13 vs. 3.63 ± 4.02; P < 0.001). The mean PHQ-9 score increased significantly with advancing 10-year ASCVD risk category in both males (from 2.03 to 2.61; P for trend < 0.001) and females (from 3.04 to 4.61; P for trend < 0.001), and the increasing trend was more apparent in females (P < 0.001). Pearson correlation analyses showed that 10-year ASCVD risk positively correlated with PHQ-9 score in both sexes (Ps < 0.001). In multivariate linear regression analyses adjusting for confounding risk factors, the independent associations of 10-year ASCVD risk with PHQ-9 score were all significant in the total (β = 2.61; P < 0.001), male (β = 1.64; P = 0.001), and female subjects (β = 3.71; P < 0.001). Further, the interaction analysis proved the impacts of 10-year ASCVD risk on PHQ-9 score were more apparent in females than males (Ps < 0.001).
The 10-year ASCVD risk was positively associated with depressive symptoms in both males and females, which was more apparent in the latter. These findings provided some novel data about the value of 10-year ASCVD risk in estimating depressive symptoms.
探讨一般人群中 10 年动脉粥样硬化性心血管疾病（ASCVD）风险与抑郁症状之间的潜在相关性。
本横断面研究纳入了中国辽宁省≥35 岁的 11956 名常住居民。采用患者健康问卷-9（PHQ-9）评估抑郁症状，使用适合中国人群的工具计算 10 年 ASCVD 风险。
男性的 10 年 ASCVD 风险显著高于女性（14.2±10.7%比 9.3±9.1%；P<0.001），但 PHQ-9 评分较低（2.34±3.13 比 3.63±4.02；P<0.001）。在男性（从 2.03 增加至 2.61；P 趋势<0.001）和女性（从 3.04 增加至 4.61；P 趋势<0.001）中，随着 10 年 ASCVD 风险类别升高，PHQ-9 评分呈显著升高趋势，且女性更为明显（P<0.001）。Pearson 相关分析显示，10 年 ASCVD 风险与两性 PHQ-9 评分呈正相关（P<0.001）。在调整混杂危险因素的多变量线性回归分析中，10 年 ASCVD 风险与 PHQ-9 评分的独立关联在总体人群（β=2.61；P<0.001）、男性（β=1.64；P=0.001）和女性人群中均具有统计学意义（β=3.71；P<0.001）。进一步的交互分析表明，10 年 ASCVD 风险对 PHQ-9 评分的影响在女性中比男性更明显（P<0.001）。
10 年 ASCVD 风险与男性和女性的抑郁症状呈正相关，在女性中更为明显。这些发现为 10 年 ASCVD 风险评估抑郁症状的价值提供了一些新的数据。
