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成人斯蒂尔病的复杂表现

Complex presentation of adult-onset Still's disease.

作者信息

Zafran Muhammad, Wassef Nancy

机构信息

Respiratory, Great Western Hospitals NHS Foundation Trust, Swindon, UK.

Cardiology, Plymouth Hospitals NHS Trust, Plymouth, UK.

出版信息

BMJ Case Rep. 2019 Apr 25;12(4):e228210. doi: 10.1136/bcr-2018-228210.

Abstract

A 61-year-old woman was admitted with feeling generally unwell with influenza-like symptoms, for almost a month. This was followed by dyspnoea, productive cough and fever of >40°C. She was started on oral antibiotics in community, but due to rising inflammatory markers, she was referred for admission to our hospital. Chest X-ray showed left basal pneumonia and SE was started on intravenous antibiotics according to microbiologist's advice. During admission she developed deranged liver functions with right upper quadrant tenderness, pleural and pericardial effusions. This was followed by multiple joint aches, mouth ulcers and a rash on her chest. Finally, after several days and clinical dilemma, she was diagnosed with adult-onset Still's disease by the rheumatologist and was started on prednisolone, to which she showed marked improvement, and was later maintained on methotrexate and hydrotherapy. She was in remission during her follow-up in the rheumatology clinic.

摘要

一名61岁女性因出现类似流感症状且身体普遍不适近一个月而入院。随后出现呼吸困难、咳痰以及体温超过40°C的发热症状。她在社区开始接受口服抗生素治疗,但由于炎症指标不断升高,被转诊至我院住院。胸部X线显示左肺底肺炎,根据微生物学家的建议,开始静脉使用抗生素治疗。住院期间,她出现肝功能紊乱,右上腹压痛,伴有胸腔和心包积液。随后出现多处关节疼痛、口腔溃疡以及胸部皮疹。最终,经过数天及临床诊断难题后,风湿科医生诊断她患成人斯蒂尔病,并开始使用泼尼松龙治疗,她的病情有明显改善,随后维持使用甲氨蝶呤及水疗。在风湿科门诊随访期间,她处于缓解期。

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本文引用的文献

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Anakinra for the treatment of adult-onset Still's disease.阿那白滞素治疗成人斯蒂尔病。
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