Seyedali Sara, Alpert Deborah R
Department of Rheumatology, Cooper University Hospital, Camden, New Jersey, USA.
Medicine/Rheumatology, Jersey Shore University Medical Center, Neptune, New Jersey, USA.
BMJ Case Rep. 2019 Apr 25;12(4):e228950. doi: 10.1136/bcr-2018-228950.
We present a 47-year-old woman with recently diagnosed systemic lupus erythematosus who developed progressive numbness and tingling of her upper and lower extremities, followed by weakness and difficulty ambulating. She was diagnosed with longitudinal extensive transverse myelitis involving her entire cervical and thoracic spinal cord. Infectious workup was unrevealing. She failed to respond to pulse-dose intravenous steroids, but slowly improved with the addition of plasmapheresis and cyclophosphamide. Following maintenance treatment with mycophenolate mofetil and slow tapering of oral steroids, she has maintained complete remission with significant recovery of neurological function.
我们报告一名47岁近期诊断为系统性红斑狼疮的女性，她出现了上下肢进行性麻木和刺痛，随后出现无力及行走困难。她被诊断为纵向广泛横贯性脊髓炎，累及整个颈段和胸段脊髓。感染方面的检查未发现异常。她对冲击剂量静脉注射类固醇治疗无反应，但在加用血浆置换和环磷酰胺后病情缓慢改善。在用霉酚酸酯维持治疗并逐渐减少口服类固醇剂量后，她保持了完全缓解，神经功能有显著恢复。
