Deakin University, Geelong, Victoria, Australia.
Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St Albans, Victoria, Australia; Department of Medicine-Western Health, The University of Melbourne, St Albans, Victoria, Australia.
Bone. 2019 Jul;124:126-131. doi: 10.1016/j.bone.2019.04.013. Epub 2019 Apr 24.
Previously we have demonstrated an association between maternal serum 25-hydroxyvitamin D (25(OH)D) during pregnancy and knee-heel length in offspring at birth. However, it is unknown whether maternal serum 25(OH)D is associated with bone measures in childhood. Thus, we aimed to examine associations between 25(OH)D at two stages of pregnancy and offspring bone measures at 11 years. Women were recruited from a single antenatal clinic in Victoria, Australia before 16 weeks gestation and provided two serum samples to determine 25(OH)D status at recruitment and 28-32 weeks gestation. Children and their mothers were followed up at 11 years of age. Children undertook dual energy X-ray absorptiometry scans at the lumbar spine and total body. Maternal 25(OH)D at recruitment (before 16 weeks gestation) was positively associated with the children's bone mineral content and density in boys, but not girls. In boys, a 10 nmol/L (4 ng/mL) increase in maternal 25(OH)D was associated with a median 0.5 g (95% CI 0.1,0.8) and 0.009 g/cm (95% CI 0.001,0.017) increase in bone mineral content and density at the spine, respectively, and a median 0.006 g/cm (95% CI 0.001,0.011) increase in at the total body. There was no sustained associations with 25(OH)D at the later timepoint (28-32 weeks) with any outcome. At age 11 years, maternal 25(OH)D levels during early pregnancy, but not late were positively associated with bone measures in boys, but not girls.
先前，我们已经证明了孕妇血清 25-羟维生素 D（25（OH）D）与出生时子女的膝-跟长度之间存在关联。然而，目前尚不清楚孕妇血清 25（OH）D 是否与儿童时期的骨骼测量值有关。因此，我们旨在研究妊娠早期和中期两个阶段的 25（OH）D 与 11 岁儿童骨骼测量值之间的关系。在澳大利亚维多利亚州的一家单一的产前诊所，在 16 周妊娠前招募了女性，并提供了两份血清样本，以确定招募时和 28-32 周妊娠时的 25（OH）D 状况。在 11 岁时对儿童及其母亲进行了随访。儿童接受了腰椎和全身双能 X 射线吸收法扫描。招募时（妊娠前 16 周）的母体 25（OH）D 与男孩的骨矿物质含量和密度呈正相关，但与女孩无关。在男孩中，母体 25（OH）D 增加 10nmol/L（4ng/mL），与脊柱骨矿物质含量和密度中位数分别增加 0.5g（95%CI 0.1，0.8）和 0.009g/cm（95%CI 0.001，0.017），全身骨矿物质含量中位数增加 0.006g/cm（95%CI 0.001，0.011）。在较晚的时间点（28-32 周），与任何结果均无持续的 25（OH）D 关联。在 11 岁时，妊娠早期而非晚期的母体 25（OH）D 水平与男孩的骨骼测量值呈正相关，但与女孩无关。
