IMPACT, The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC, 3220, Australia.
Barwon Health, Geelong, VIC, 3220, Australia.
Arch Osteoporos. 2021 Oct 27;16(1):159. doi: 10.1007/s11657-021-01023-3.
Vitamin D is important for bone health and strength. Previous studies report 25-hydroxyvitamin D (25(OH)D) exposure during pregnancy may impact offspring bone health later in life. In this study, maternal 25(OH)D at recruitment was associated with a lower fracture risk in boys and an increased fracture risk in girls at 28-32 weeks gestation.
Maternal 25-hydroxyvitamin D (25(OH)D) in pregnancy has been shown to be associated with offspring bone measures in some studies, but few have examined fracture risk. We aimed to determine associations between maternal vitamin D status and offspring fracture risk.
In total, 475 mother-child pairs participating in the Vitamin D in Pregnancy study in southeastern Australia were recruited. Maternal serum samples were taken at recruitment (< 16 weeks gestation) and/or 28-32 weeks gestation and analysed for 25(OH)D. Incident fractures in children were ascertained from date of birth (2002-2004) until December 31, 2012. Cox proportional hazard models included maternal age at recruitment, offspring sex, birth weight, gestation length and season of vitamin D sample.
Complete follow-up data were available for 400 children (median age = 9.5 years). There were 68 (17.0%) children who sustained at least one fracture. Higher maternal 25(OH)D (per 10 nmol/L) in early gestation was weakly associated with a decreased fracture risk in boys (HR 0.82; 95% CI 0.68, 0.99; p = 0.048) but not girls (HR 1.10; 95% CI 0.98, 1.25; p = 0.11). At late gestation, higher maternal 25(OH)D was associated with increased fracture risk in girls (HR 1.11; 95% CI 1.01, 1.23; p = 0.038) but not boys (HR 0.94; 95% CI 0.80, 1.10; p = 0.42). No statistically significant relationships were detected in analyses investigating 25(OH)D as a categorical variable.
There is some evidence that higher maternal 25(OH)D at recruitment was associated with lower fracture risk in boys, while higher maternal 25(OH)D at 28-32 weeks gestation was associated with an increased fracture risk in girls.
维生素 D 对骨骼健康和强度很重要。先前的研究报告表明，孕妇 25-羟维生素 D（25（OH）D）的暴露可能会影响后代日后的骨骼健康。在这项研究中，招募时的母体 25（OH）D 与 28-32 周妊娠时男孩骨折风险降低和女孩骨折风险增加相关。
一些研究表明，孕妇 25-羟维生素 D（25（OH）D）与后代的骨骼测量值有关，但很少有研究检查骨折风险。我们旨在确定母体维生素 D 状况与后代骨折风险之间的关系。
总共招募了 475 对参与澳大利亚东南部维生素 D 妊娠研究的母婴对。在招募时（<16 周妊娠）和/或 28-32 周妊娠时采集母体血清样本，并分析 25（OH）D。从出生日期（2002-2004 年）到 2012 年 12 月 31 日，通过儿童骨折确定儿童的事件性骨折。Cox 比例风险模型包括招募时的母体年龄、后代性别、出生体重、胎龄和维生素 D 样本季节。
对于 400 名儿童（中位年龄=9.5 岁），可获得完整的随访数据。有 68 名（17.0%）儿童至少发生了一次骨折。早期妊娠中母体 25（OH）D 每增加 10nmol/L，男孩的骨折风险降低（HR 0.82；95%CI 0.68,0.99;p=0.048），但女孩没有（HR 1.10；95%CI 0.98,1.25;p=0.11）。在妊娠晚期，母体 25（OH）D 升高与女孩的骨折风险增加相关（HR 1.11；95%CI 1.01,1.23;p=0.038），但与男孩无关（HR 0.94；95%CI 0.80,1.10;p=0.42）。在调查 25（OH）D 作为分类变量的分析中，未发现具有统计学意义的关系。
有一些证据表明，招募时母体 25（OH）D 较高与男孩骨折风险降低有关，而 28-32 周妊娠时母体 25（OH）D 较高与女孩骨折风险增加有关。
