Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Nutrition. 2019 Jul-Aug;63-64:141-147. doi: 10.1016/j.nut.2019.02.004. Epub 2019 Feb 19.
To our knowledge, no studies have examined the association between the empirically derived food-based dietary inflammatory index (FDII) and irritable bowel syndrome (IBS). The aim of this study was to examine the relationship between the FDII score and IBS in a large sample of Iranian adults.
In this cross-sectional study, the dietary intakes of 3363 adults were assessed using a validated dish-based 106-item semi-quantitative food frequency questionnaire (DS-FFQ). The FDII was calculated based on the dietary intakes of food groups derived from DS-FFQ. IBS was assessed using a modified Persian version of the Rome III questionnaire.
Participants in the top quintile of the FDII score had a 42% greater risk for IBS than those in the bottom quintile (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.08-1.88). Among women, we observed a significant direct association between the FDII score and IBS after adjustment for potential confounders (OR, 1.44; 95% CI, 1.01-2.04). By body mass index (BMI) status, normal weight subjects (BMI <25 kg/m) in the top quintile of the FDII score had higher risk for IBS (OR, 1.60; 95% CI, 1.07-2.35) than those in the bottom quintile. These associations were not observed in men or in participants with a BMI ≥25 kg/m. There was no significant association between the FDII score and IBS subtypes. No significant association between the FDII score and IBS severity was observed.
Consumption of a pro-inflammatory diet was associated with increased risk for IBS, especially in women and in individuals with a BMI <25 kg/m.
据我们所知，尚无研究探讨经验衍生的食物炎症指数（FDII）与肠易激综合征（IBS）之间的关联。本研究旨在检查伊朗成年人中较大样本中 FDII 评分与 IBS 之间的关系。
在这项横断面研究中，使用经过验证的基于碟式的 106 项半定量食物频率问卷（DS-FFQ）评估了 3363 名成年人的饮食摄入量。FDII 是根据 DS-FFQ 中食物组的饮食摄入量计算得出的。使用改良的罗马 III 问卷评估 IBS。
FDII 评分最高五分位组的 IBS 风险比最低五分位组高 42%（比值比 [OR]，1.42；95%置信区间 [CI]，1.08-1.88）。在女性中，我们观察到在调整潜在混杂因素后，FDII 评分与 IBS 之间存在直接关联（OR，1.44；95%CI，1.01-2.04）。按体重指数（BMI）状态分层，FDII 评分最高五分位组的正常体重受试者（BMI<25 kg/m）患 IBS 的风险高于最低五分位组（OR，1.60；95%CI，1.07-2.35）。这些关联在男性或 BMI≥25 kg/m 的参与者中均未观察到。FDII 评分与 IBS 亚型之间无显著关联。FDII 评分与 IBS 严重程度之间也无显著关联。
食用促炎饮食与 IBS 的风险增加相关，尤其是在女性和 BMI<25 kg/m 的个体中。
