Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Nutr Neurosci. 2021 Apr;24(4):260-268. doi: 10.1080/1028415X.2019.1621044. Epub 2019 Aug 1.
There is no study on the association of empirically derived food-based dietary inflammatory index (FDII) and risk of psychological disorders. We investigated the association between FDII and odds of psychological disorders in Iranian adults. In this cross-sectional study, data on dietary intakes of 3363 Iranian adult participants were collected using a validated dish-based 106-item semi-quantitative food frequency questionnaire. FDII score was constructed based on participants' dietary intakes of 28 pre-defined food groups. The Iranian validated version of Hospital Anxiety and Depression Scale (HADS) and General Health Questionnaire (GHQ) was used to assess psychological disorders. Depression, anxiety and psychological distress were defined based on standard criteria. After controlling for potential confounders, participants in the top quintile of FDII score had a greater odds of depression (OR: 1.49; 95% CI: 1.08-2.06), anxiety (OR: 1.92; 95% CI: 1.24-2.96), and psychological distress (OR: 1.55; 95% CI: 1.10-2.19) compared with those in the bottom quintile. When we did the analyses stratified by gender, we found a significant positive association between FDII score and depression (OR: 1.57; 95% CI: 1.04-2.35), anxiety (OR: 1.99; 95% CI: 1.19-3.34), and psychological distress (OR: 1.68; 95% CI: 1.10-2.56) among women comparing the highest and the lowest quintiles. We found no significant association between FDII score and psychological disorders in men. We found that greater FDII score was positively associated with psychological disorders. In the gender-stratified analysis, this was seen in women but not in men.
目前尚无研究探讨经验衍生的基于食物的饮食炎症指数（FDII）与心理障碍风险之间的关联。本研究旨在调查伊朗成年人中 FDII 与心理障碍发生几率之间的关系。在这项横断面研究中，我们采用经过验证的基于菜肴的 106 项半定量食物频率问卷收集了 3363 名伊朗成年参与者的饮食摄入数据。FDII 评分基于参与者对 28 种预先定义食物组的饮食摄入情况进行构建。采用经过伊朗验证的医院焦虑和抑郁量表（HADS）和一般健康问卷（GHQ）评估心理障碍。根据标准标准定义了抑郁、焦虑和心理困扰。在控制了潜在混杂因素后，FDII 评分最高五分位的参与者发生抑郁（OR：1.49；95%CI：1.08-2.06）、焦虑（OR：1.92；95%CI：1.24-2.96）和心理困扰（OR：1.55；95%CI：1.10-2.19）的几率高于最低五分位的参与者。当我们按性别进行分层分析时，我们发现 FDII 评分与女性的抑郁（OR：1.57；95%CI：1.04-2.35）、焦虑（OR：1.99；95%CI：1.19-3.34）和心理困扰（OR：1.68；95%CI：1.10-2.56）之间存在显著正相关，最高五分位与最低五分位相比。我们未发现 FDII 评分与男性心理障碍之间存在显著关联。我们发现，较高的 FDII 评分与心理障碍呈正相关。在性别分层分析中，这一关联仅见于女性，而男性则不然。
