Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China; Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, P.O. Box 1109, Blindern, NO-0317 Oslo, Norway.
Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China.
Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:232-242. doi: 10.1016/j.msec.2019.03.091. Epub 2019 Mar 27.
Polyetheretherketone (PEEK) has been used in orthopedic surgery for several decades. Numerous methods were invented to alter the properties of PEEK. By adding nanoparticles, fibers, etc., elastic modulus and strength of PEEK can be changed to meet certain demand. In this study, tantalum (Ta), a promising metal, was introduced to modify the properties of PEEK, in which PEEK was reinforced with different contents of tantalum nanoparticles (from 1 wt% to 9 wt%). Mechanical properties and biological functions (both in vitro and in vivo) were then investigated. The highest elastic modulus and compressive strength were observed in 3%Ta-PEEK. Cell experiments as cell adhesion, collagen secretion, biomineralization and osteogenesis related gene expression showed preferable results in 3%Ta-PEEK and 5%Ta-PEEK. Improved bone integration was shown in 3%Ta-PEEK and 5%Ta-PEEK in vivo. Above all, enhanced mechanical properties and promoted bone formation were proved for 3%Ta-PEEK and 5%Ta-PEEK compared to others groups both in vitro and in vivo, suggesting that the addition of tantalum nanoparticles modified the osseointegration ability of PEEK. This composite of tantalum and PEEK could have a clinical potential for orthopedic implants.
聚醚醚酮（PEEK）在骨科手术中已经使用了几十年。人们发明了许多方法来改变 PEEK 的性能。通过添加纳米粒子、纤维等，可以改变 PEEK 的弹性模量和强度，以满足特定需求。在这项研究中，钽（Ta）作为一种很有前途的金属，被引入到 PEEK 的改性中，其中 PEEK 中加入了不同含量的钽纳米粒子（从 1wt%到 9wt%）。然后研究了其力学性能和生物学功能（体外和体内）。在 3%Ta-PEEK 中观察到最高的弹性模量和压缩强度。细胞实验如细胞黏附、胶原蛋白分泌、生物矿化和成骨相关基因表达，在 3%Ta-PEEK 和 5%Ta-PEEK 中显示出更好的结果。在体内，3%Ta-PEEK 和 5%Ta-PEEK 显示出更好的骨整合。总之，与其他组相比，3%Ta-PEEK 和 5%Ta-PEEK 在体外和体内都表现出增强的力学性能和促进骨形成的能力，这表明添加钽纳米粒子可以改变 PEEK 的骨整合能力。这种钽和 PEEK 的复合材料可能具有用于骨科植入物的临床潜力。
