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氧化铜/碳纳米复合物:以蔗糖为碳源的合成与优化及其抗真菌活性。

CuO/C nanocomposite: Synthesis and optimization using sucrose as carbon source and its antifungal activity.

机构信息

Chemistry of Heterocycles & Natural Product Research Laboratory, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632 014, Tamilnadu, India.

Chemistry of Heterocycles & Natural Product Research Laboratory, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632 014, Tamilnadu, India.

出版信息

Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:404-414. doi: 10.1016/j.msec.2019.03.105. Epub 2019 Mar 30.

Abstract

The synthesis of bioactive CuO/C nano composite using sucrose as a capping agent is achieved through simple green approach via Response Surface Methodology. The synthesis process was done in a green environment which prevents aggregation of sucrose and promotes nanoparticles formation. The innovative approach produces sucrose as a carbon source mediated copper oxide nanocomposites (CuO/C nanocomposite) with the particle size of 50 nm. Additionally, the produced CuO/C nanocomposite were characterized using microscopic techniques like SEM, TEM and spectroscopic techniques like UV-vis and X-ray diffraction. The antifungal activities of CuO/C nanocomposite were tested against Aspergillus niger and Aspergillus flavus species. At 1000 ppm of CuO/C nanocomposite, it showed 70% restraint on A. flavus and 90% hindrance on A. niger. The fungal inhibition mechanism of bioactive CuO/C nanocomposite was discussed in this research article. The particular high antifungal performance of CuO/C nanocomposite was found against Aspergillus niger while compare to Aspergillus flavus fungal strain.

摘要

采用响应面法,通过简单的绿色方法合成了以蔗糖为封端剂的生物活性 CuO/C 纳米复合材料。合成过程在绿色环境中进行,可防止蔗糖聚集并促进纳米颗粒的形成。这种创新方法以蔗糖作为碳源,制备出粒径为 50nm 的氧化铜纳米复合材料(CuO/C 纳米复合材料)。此外,还使用 SEM、TEM 等微观技术和 UV-vis、X 射线衍射等光谱技术对所制备的 CuO/C 纳米复合材料进行了表征。测试了 CuO/C 纳米复合材料对黑曲霉和黄曲霉的抗真菌活性。在 1000ppm 的 CuO/C 纳米复合材料下,对黄曲霉的抑制率达到 70%,对黑曲霉的抑制率达到 90%。本文讨论了生物活性 CuO/C 纳米复合材料的抑菌机制。与黄曲霉真菌菌株相比,CuO/C 纳米复合材料对黑曲霉的抗真菌性能特别高。

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