F Sherin Rebecca, V Vidhya Lakshmi, M Jeyashree, A Elavarasi, Rajamanickam Ponnivedha
PG and Research Centre of Zoology, Jayaraj Annapackiam College for Women (Autonomous) Periyakulam, Theni, Tamilnadu, India.
DBT-BIF Centre, PG and Research Department of Biotechnology and Bioinformatics, Holy Cross College, Affiliated to Bharathidasan University, Tiruchirappalli-620 002, Tamil Nadu, India.
Bioinformation. 2023 Feb 28;19(2):190-195. doi: 10.6026/97320630019190. eCollection 2023.
Medicinal plants are considered to be the source of richness in Traditional Medicine. The chosen plants Mollugocerviana (L.) and Mukiamaderas patina. (L.) are commonly used to treat various ailments in traditional medicine. In the present study these two Plants were extracted with Ethanol and were subjected to Phytochemical Analysis to confirm the presence of different Phytochemicals. After phytochemical analysis the antimicrobial efficiency of the Plant extracts were checked against different microbial pathogens. The results confirm that the combined extract of both the plants shows potent activity against selected pathogenic strains. The results clearly indicate that the activity is in a dose dependent manner which is defined as higher the concentration higher the activity. GC-MS analysis of the extracts showed the presence of Ergost-7-en-3-ol. This ligand was docked with TyRs protein of to understand the interactions and predict the affinity and the activity of the potent bioactive molecules. It shows promising interaction with respect to binding poses of interacted complex. From the current study it is proved that the chosen plants are highly loaded with nutrients and can be used as a drug target in future. Further studies are required to confirm the efficiency of the plant extracts.
药用植物被认为是传统医学丰富性的来源。所选植物Mollugocerviana (L.) 和Mukiamaderas patina. (L.) 在传统医学中常用于治疗各种疾病。在本研究中，这两种植物用乙醇提取，并进行植物化学分析以确认不同植物化学物质的存在。植物提取物的抗菌效率在植物化学分析后针对不同的微生物病原体进行了检测。结果证实，两种植物的联合提取物对选定的致病菌株显示出强大的活性。结果清楚地表明，活性呈剂量依赖性，即浓度越高活性越高。提取物的气相色谱-质谱联用（GC-MS）分析显示存在麦角甾-7-烯-3-醇。该配体与 的酪氨酸受体（TyRs）蛋白对接，以了解相互作用并预测有效生物活性分子的亲和力和活性。就相互作用复合物的结合构象而言，它显示出有前景的相互作用。从目前的研究证明，所选植物富含营养成分，未来可作为药物靶点。需要进一步研究来确认植物提取物的效率。
