Department of Chemistry , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 , United States.
J Am Chem Soc. 2019 May 15;141(19):7709-7714. doi: 10.1021/jacs.9b02844. Epub 2019 May 3.
Metal-hydride hydrogen atom transfer (MHAT) functionalizes alkenes with predictable branched (Markovnikov) selectivity. The breadth of these transformations has been confined to π-radical traps; no sp electrophiles have been reported. Here we describe a Mn/Ni dual catalytic system that hydroalkylates unactivated olefins with unactivated alkyl halides, yielding aliphatic quaternary carbons.
金属氢化物氢原子转移 (MHAT) 可实现烯烃的功能化，具有可预测的支链（马氏规则）选择性。这些转化的范围仅限于π-自由基陷阱；尚未报道 sp 亲电试剂。在这里，我们描述了一种 Mn/Ni 双催化体系，可将未活化的烯烃与未活化的烷基卤化物氢烷基化，生成脂肪族季碳。
