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Indian J Microbiol. 2019 Jun;59(2):241-245. doi: 10.1007/s12088-018-0774-5. Epub 2018 Dec 28.
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本文引用的文献

1
Klebsiella pneumoniae secretes outer membrane vesicles that induce the innate immune response.肺炎克雷伯菌分泌的外膜囊泡会诱导先天免疫反应。
FEMS Microbiol Lett. 2012 Jun;331(1):17-24. doi: 10.1111/j.1574-6968.2012.02549.x. Epub 2012 Apr 13.
2
Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression.血红素加氧酶-1 将线粒体生物发生的激活与抗炎细胞因子的表达偶联。
J Biol Chem. 2011 May 6;286(18):16374-85. doi: 10.1074/jbc.M110.207738. Epub 2011 Mar 18.
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Biological functions and biogenesis of secreted bacterial outer membrane vesicles.分泌型细菌外膜囊泡的生物学功能与生物发生。
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Outer membrane vesicle-mediated release of cytolethal distending toxin (CDT) from Campylobacter jejuni.空肠弯曲菌外膜囊泡介导的细胞致死性扩张毒素（CDT）释放
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Bacterial quorum-sensing network architectures.细菌群体感应网络架构
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Klebsiella pneumoniae triggers a cytotoxic effect on airway epithelial cells.肺炎克雷伯菌对气道上皮细胞产生细胞毒性作用。
BMC Microbiol. 2009 Aug 3;9:156. doi: 10.1186/1471-2180-9-156.
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The changing face of Klebsiella pneumoniae infections in the community.社区中肺炎克雷伯菌感染情况的变化
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Special delivery: vesicle trafficking in prokaryotes.特刊：原核生物中的囊泡运输
Mol Microbiol. 2006 Aug;61(4):839-46. doi: 10.1111/j.1365-2958.2006.05272.x.
9
Purification of outer membrane vesicles from Pseudomonas aeruginosa and their activation of an IL-8 response.从铜绿假单胞菌中纯化外膜囊泡及其对白细胞介素-8反应的激活作用。
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Outer membrane vesicles of the VA-MENGOC-BC vaccine against serogroup B of Neisseria meningitidis: Analysis of protein components by two-dimensional gel electrophoresis and mass spectrometry.针对B群脑膜炎奈瑟菌的VA-MENGOC-BC疫苗的外膜囊泡：通过二维凝胶电泳和质谱分析蛋白质成分
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人类上皮细胞和肥大细胞中基因表达对美国典型培养物保藏中心13883株菌来源的囊泡的响应变化

Changes in Gene Expression in Human Epithelial and Mast Cells in Response to Vesicles from ATCC 13883.

作者信息

You Hee Sang, Ok Yeon Jeong, Lee Song Hee, Kang Sang Sun, Hyun Sung Hee

机构信息

1Department of Biomedical Laboratory Science, School of Medicine, Eulji University, #143-5, Yongdu-dong, Jung-gu, Daejeon, 301-746 Republic of Korea.

2BK21 Plus Program, Department of Senior Healthcare, Graduate School, Eulji University, Daejeon, Republic of Korea.

出版信息

Indian J Microbiol. 2019 Jun;59(2):241-245. doi: 10.1007/s12088-018-0774-5. Epub 2018 Dec 28.

DOI:10.1007/s12088-018-0774-5
PMID:31031441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6458193/
Abstract

We investigated alterations in the expression of immune-related genes in epithelial cells and mast cells treated with outer membrane vesicles (OMVs) derived from e (KpOMVs). Previous studies have shown that OMVs contain substances that enable their delivery to host cells and induce an immune response. Our results indicate an increase in expression of genes such as -, -, -, , and - in epithelial cells and mast cells treated with KpOMVs. The pathogenicity of KpOMVs was confirmed by measuring the changes in the expression of these immune-related genes.

摘要

我们研究了用肺炎克雷伯菌外膜囊泡（KpOMVs）处理的上皮细胞和肥大细胞中免疫相关基因表达的变化。先前的研究表明，外膜囊泡含有能够使其递送至宿主细胞并诱导免疫反应的物质。我们的结果表明，在用KpOMVs处理的上皮细胞和肥大细胞中，诸如-、-、-、、和-等基因的表达增加。通过测量这些免疫相关基因表达的变化证实了KpOMVs的致病性。