Li Kan Yan Chloe
Institute of Cardiovascular Science, University College London, London, United Kingdom.
Front Cardiovasc Med. 2019 Apr 11;6:47. doi: 10.3389/fcvm.2019.00047. eCollection 2019.
Prosthetic heart valves have been commonly used to address the increasing prevalence of valvular heart disease. The ideal prosthetic heart valve substitute should closely mimic the characteristics of a normal native heart valve. Despite the development of various interventions, an exemplary valve replacement does not exist. This review provides an overview of the novel engineering valve designs and explores emergent immunologic insights into age-dependent structural valve degeneration (SVD).
人工心脏瓣膜已被广泛用于应对日益增多的心脏瓣膜病。理想的人工心脏瓣膜替代品应紧密模仿正常天然心脏瓣膜的特性。尽管已开展了各种干预措施，但仍不存在堪称典范的瓣膜置换物。本综述概述了新型工程瓣膜设计，并探讨了针对年龄依赖性结构性瓣膜退变（SVD）的新出现的免疫学见解。
