Cao Qun, Stark Roderick T, Fallis Ian A, Browne Duncan L
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.
ChemSusChem. 2019 Jun 21;12(12):2554-2557. doi: 10.1002/cssc.201900886. Epub 2019 Jun 5.
An operationally simple one-jar one-step mechanochemical Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features of this reaction protocol are that it requires no solvent, no inert gases, and no pre-activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39-82 % yield) and is effective irrespective of the initial morphology of the zinc source.
已经开发出一种操作简单的单罐一步机械化学Reformatsky反应，该反应在纯研磨条件下使用原位生成的有机锌中间体。该反应方案的显著特点是不需要溶剂、不需要惰性气体，也不需要对大量锌源进行预活化。结果表明，所开发的方法具有良好的底物范围（产率39-82%），并且无论锌源的初始形态如何均有效。
