球磨条件下机械化学锌介导的巴尔比耶型烯丙基化反应。
A Mechanochemical Zinc-Mediated Barbier-Type Allylation Reaction under Ball-Milling Conditions.
机构信息
School of Chemistry , Cardiff University , Main Building, Park Place , Cardiff CF10 3AT , U.K.
出版信息
J Org Chem. 2020 Feb 21;85(4):2347-2354. doi: 10.1021/acs.joc.9b02876. Epub 2020 Jan 8.
PMID:31913623
Abstract
A ball-milling-enabled zinc-mediated Barbier-type allylation reaction is reported. Notably, running the reaction in this manner renders it effective irrespective of the initial morphology of the zinc metal. The process is operationally simple, does not require inert atmospheres or dry solvents, and is reported over a range of aldehyde and ketone substrates; a gram-scale process is demonstrated.
摘要
本文报道了一种通过球磨实现的锌介导的巴尔比耶型烯丙基化反应。值得注意的是，以这种方式进行反应，无论锌金属的初始形态如何，都能有效地进行。该过程操作简单，不需要惰性气氛或干燥溶剂，并且在一系列醛和酮底物中都有报道；还展示了克级规模的反应过程。
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