通过球磨实现的稳健钯催化碳-硫交叉偶联反应过程
A Robust Pd-Catalyzed C-S Cross-Coupling Process Enabled by Ball-Milling.
作者信息
Jones Andrew C, Nicholson William I, Smallman Harry R, Browne Duncan L
机构信息
Cardiff Catalysis Institute, School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, U.K.
School of Pharmacy, UCL, 29-39 Brunswick Square, London WC1X 1AX, U.K.
出版信息
Org Lett. 2020 Oct 2;22(19):7433-7438. doi: 10.1021/acs.orglett.0c02418. Epub 2020 Sep 17.
An operationally simple mechanochemical C-S coupling of aryl halides with thiols has been developed. The reaction process operates under benchtop conditions without the requirement for a (dry) solvent, an inert atmosphere, or catalyst preactivation. The reaction is finished within 3 h. The reaction is demonstrated across a broad range of substrates; the inclusion of zinc metal has been found to be critical in some instances, especially for coupling of alkyl thiols.
已开发出一种操作简单的芳基卤化物与硫醇的机械化学碳-硫偶联反应。该反应过程在台式条件下进行，无需（干燥）溶剂、惰性气氛或催化剂预活化。反应在3小时内完成。该反应在广泛的底物范围内得到证实；已发现加入锌金属在某些情况下至关重要，特别是对于烷基硫醇的偶联。
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