Nakajima T, Watanabe S, Sato Y, Kameya T, Hirota T, Shimosato Y
Am J Surg Pathol. 1982 Dec;6(8):715-27. doi: 10.1097/00000478-198212000-00003.
The presence of S-100 protein was immunohistochemically studied in many types of formalin-fixed and paraffin-embedded tumors (260 cases). Peripheral nerve tumors, i.e., schwannomas, neurofibromas, granular cell tumors, and neurogenic sarcomas were demonstrated to contain variable amounts of S-100 protein in the tumor cell cytoplasm and nuclei. In ganglioneuromas and ganglioneuroblastomas, neoplastic Schwann cells or satellite cells were positive for S-100 protein. About one-half of the cases of carcinoid tumors stained weakly for S-100 protein. In addition to these nervous tissue and carcinoid tumors, chondrosarcoma, chordomas, pleomorphic adenomas of the salivary gland, and Langerhans cell granulomatosis were also shown to produce S-100 protein. In many types of breast tumors and other lesions, S-100 protein positive cells were likely to correspond to the distribution of myoepithelial cells. These results indicate that S-100 protein is not strictly specific to nervous tissue and its tumors; however, the immunohistochemical demonstration of S-100 protein can be a useful diagnostic tool in tumor diagnosis.
采用免疫组织化学方法对多种福尔马林固定、石蜡包埋的肿瘤（260例）进行了S-100蛋白检测。结果显示，周围神经肿瘤，即神经鞘瘤、神经纤维瘤、颗粒细胞瘤和神经源性肉瘤，肿瘤细胞的细胞质和细胞核内含有不同量的S-100蛋白。在神经节神经瘤和神经节神经母细胞瘤中，肿瘤性施万细胞或卫星细胞S-100蛋白呈阳性。约半数类癌肿瘤S-100蛋白染色弱阳性。除了这些神经组织和类癌肿瘤外，软骨肉瘤、脊索瘤、涎腺多形性腺瘤和朗格汉斯细胞肉芽肿也被证明可产生S-100蛋白。在多种乳腺肿瘤和其他病变中，S-100蛋白阳性细胞可能与肌上皮细胞的分布一致。这些结果表明，S-100蛋白并非严格特异性地存在于神经组织及其肿瘤中；然而，S-100蛋白的免疫组织化学检测在肿瘤诊断中可能是一种有用的诊断工具。
