Chen Jing, Xie Lin
Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, Ontario, Canada.
Centre for Surveillance and Applied Research, Public Health Agency Canada, 785 Carling Avenue, Ottawa, Ontario, Canada.
Radiat Prot Dosimetry. 2019 Oct 1;184(3-4):486-492. doi: 10.1093/rpd/ncz068.
In this paper, we revisit the possibility, first raised using a data set collected in the 1970s, that there is a link between average radon concentrations and the incidence of childhood leukaemia and lymphoma in Canada. Following the launch of the National Radon Program in 2007, Health Canada completed a long-term radon survey in 33 census metropolitan areas (CMAs), which covers about 70% of the Canadian population. We used this data, together with leukaemia and lymphoma incidence rates among children (0-14 years of age) in the past decade (2006-15), and tried to link the city-level average radon concentrations to the leukaemia and lymphoma incidence rates in 33 major Canadian cities. Analyses were conducted for six subtypes (ALL, AML, CMD, HL, NHL and BL) of leukaemia and lymphoma. Estimated doses to red bone marrow from domestic radon exposure were low and we did not find any association between radon exposure at home and the increased risk for developing leukaemia among children under 15 years of age living in the CMAs. The results indicate a slight positive association for AML among 1-4 year males in CMAs of Peer Group C and NHL among 5-9 year females in CMAs of Peer Group A; however, these should be interpreted with caution owing to the crude exposure assessment and possibilities of other confounding factors.
在本文中，我们重新审视了一个可能性，该可能性最初是利用20世纪70年代收集的数据集提出的，即加拿大平均氡浓度与儿童白血病和淋巴瘤发病率之间存在联系。2007年国家氡计划启动后，加拿大卫生部在33个人口普查大都市区（CMA）完成了一项长期氡调查，覆盖了约70%的加拿大人口。我们使用了这些数据，以及过去十年（2006 - 2015年）0至14岁儿童的白血病和淋巴瘤发病率，并试图将城市层面的平均氡浓度与加拿大33个主要城市的白血病和淋巴瘤发病率联系起来。对白血病和淋巴瘤的六个亚型（急性淋巴细胞白血病、急性髓细胞白血病、慢性髓性白血病、霍奇金淋巴瘤、非霍奇金淋巴瘤和伯基特淋巴瘤）进行了分析。家庭氡暴露对红骨髓的估计剂量较低，我们没有发现居住在人口普查大都市区的15岁以下儿童在家中接触氡与患白血病风险增加之间存在任何关联。结果表明，在C组人口普查大都市区1 - 4岁男性的急性髓细胞白血病以及A组人口普查大都市区5 - 9岁女性的非霍奇金淋巴瘤之间存在轻微的正相关；然而，由于粗略的暴露评估以及其他混杂因素的可能性，这些结果应谨慎解读。
