Department of Medical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Morris Animal Foundation, Denver, Colorado, USA.
J Vet Intern Med. 2024 May-Jun;38(3):1659-1665. doi: 10.1111/jvim.17021. Epub 2024 Mar 4.
Multicentric lymphoma (ML) in dogs resembles non-Hodgkin lymphoma (NHL) in humans. Human NHL is associated with multiple environmental exposures, including to radon and volatile organic compounds (VOCs).
HYPOTHESIS/OBJECTIVES: The objective of this study was to determine whether ML in dogs was associated with environmental radon or proximity to horizontal oil and drilling (fracking), a source of VOC pollution.
We identified dogs from the Golden Retriever Lifetime Study that developed ML (n = 52) along with matched controls (n = 104). Dog home addresses were categorized by Environmental Protection Agency radon zone and average residential radon by county, as well as by distance from fracking and associated wastewater wells.
We found no significant differences in county level radon measurements. Individual household radon measurements were not available. There was no difference in residential proximity to active fracking wells between dogs with ML and unaffected dogs. While dogs with ML lived closer to wastewater wells (123 vs 206 km; P = .01), there was no difference in the percentage of cases vs controls that lived in close proximity (20 km) to a fracking well (11.5% for cases, 6.7% for controls; OR 1.81, 95% CI 0.55 to 5.22; P = .36), or a wastewater well (6.7% for cases, 4.4% for controls; P > .99).
These data suggest that more proximate sources of chemical exposures need to be assessed in dogs with ML, including measurements of individual household radon and household VOC concentrations.
犬多中心性淋巴瘤（ML）类似于人类的非霍奇金淋巴瘤（NHL）。人类 NHL 与多种环境暴露有关，包括氡和挥发性有机化合物（VOC）。
假设/目的：本研究旨在确定犬 ML 是否与环境氡或靠近水平石油和钻井（水力压裂）有关，后者是 VOC 污染的来源。
我们从金猎犬终身研究中确定了患有 ML（n = 52）的犬以及匹配的对照犬（n = 104）。根据环境保护署的氡区和按县划分的平均住宅氡，以及与水力压裂和相关废水井的距离，对犬的家庭住址进行分类。
我们没有发现县一级氡测量值存在显著差异。无法获得个别家庭的氡测量值。患有 ML 的犬与未受影响的犬之间，住宅与活跃的水力压裂井之间的距离没有差异。虽然患有 ML 的犬离废水井更近（123 与 206 km；P = .01），但病例组与对照组中靠近水力压裂井（20 km）生活的比例没有差异（11.5%病例组，6.7%对照组；OR 1.81，95%CI 0.55 至 5.22；P = .36），或靠近废水井（6.7%病例组，4.4%对照组；P > .99）。
这些数据表明，需要在患有 ML 的犬中评估更接近的化学暴露源，包括测量个别家庭的氡和家庭 VOC 浓度。
