Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic; Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 121 08 Prague 2, Czech Republic; Na Homolce Hospital, Prague 5, Czech Republic.
Clin Biochem. 2019 Oct;72:3-6. doi: 10.1016/j.clinbiochem.2019.04.015. Epub 2019 Apr 26.
Alzheimer's disease is a progressive, irreversible, incurable, neurodegenerative illness and the most common of the dementing disorders. It starts usually after 60 years of age and may span 8 to 12 years. The continuous and slow decline caused by this disease, is characterized by cognitive deterioration, loss of functional independence, changes in behaviour, and expanding needs for care. In the last three decades, the proteins predominating neuritic plaques and neurofibrillary tangles have been detected and researched: amyloid-beta protein in the plaques and hyperphosphorylated tau in the tangles. Alzheimer's disease is now considered a long-term process with a slow progress and with a prolonged development of pathological changes that precedes symptoms by years. AD is becoming one of the most problematic and expensive illness for the civilization, also known as "silent threat".
阿尔茨海默病是一种进行性、不可逆、无法治愈的神经退行性疾病，也是最常见的痴呆症之一。它通常始于 60 岁以后，可能持续 8 到 12 年。这种疾病引起的持续和缓慢的衰退，其特征是认知能力下降、丧失功能独立性、行为改变和不断扩大的护理需求。在过去的三十年中，已经检测和研究了主导神经纤维缠结和神经原纤维缠结的蛋白质：斑块中的淀粉样β蛋白和缠结中的过度磷酸化 tau 蛋白。现在认为阿尔茨海默病是一个长期的过程，进展缓慢，病理变化的发展时间比症状出现早数年。AD 正成为文明社会最具问题性和最昂贵的疾病之一，也被称为“无声的威胁”。
