Lerche Marianne, Bailis Nikolaos, Akritidou Mideia, Meyer Hans Jonas, Surov Alexey
Department of Respiratory Medicine, University of Leipzig, Liebigstr. 20, 04103 Leipzig, Germany.
Department of Radiology, University of Leipzig, Liebigstr. 20, 04103 Leipzig, Germany.
J Clin Med. 2019 Apr 28;8(5):584. doi: 10.3390/jcm8050584.
The aim of the present study was to analyze possible relationships between pulmonary vessel obstruction and clinically relevant parameters and scores in patients with pulmonary embolism (PE). Overall, 246 patients (48.8% women and 51.2% men) with a mean age of 64.0 ± 17.1 years were involved in the retrospective study. The following clinical scores were calculated in the patients: Wells score, Geneva score, and pulmonary embolism severity index (PESI) score. Levels of D-dimer (µg/mL), lactate, pH, troponin, and N-terminal natriuretic peptide (BNP, pg/mL) were acquired. Thrombotic obstruction of the pulmonary arteries was quantified according to Mastora score. The data collected were evaluated by means of descriptive statistics. Spearman's correlation coefficient was used to analyze associations between the investigated parameters. values < 0.05 were taken to indicate statistical significance. Mastora score correlated weakly with lactate level and tended to correlate with D-dimer and BNP levels. No other clinical or serological parameters correlated significantly with clot burden. Thrombotic obstruction of pulmonary vessels did not correlate with clinical severity of PE.
本研究的目的是分析肺栓塞(PE)患者肺血管阻塞与临床相关参数及评分之间的可能关系。总体而言,246例患者(女性占48.8%,男性占51.2%)参与了这项回顾性研究,平均年龄为64.0±17.1岁。在患者中计算了以下临床评分:Wells评分、Geneva评分和肺栓塞严重程度指数(PESI)评分。获取了D-二聚体(μg/mL)、乳酸、pH、肌钙蛋白和N末端脑钠肽(BNP,pg/mL)的水平。根据Mastora评分对肺动脉的血栓阻塞进行量化。收集的数据通过描述性统计进行评估。采用Spearman相关系数分析所研究参数之间的关联。P值<0.05被视为具有统计学意义。Mastora评分与乳酸水平弱相关,且倾向于与D-二聚体和BNP水平相关。没有其他临床或血清学参数与血栓负荷显著相关。肺血管的血栓阻塞与PE的临床严重程度无关。