Institute of Agricultural Sciences, Universidade dos Vales do Jequitinhonha e Mucuri-UFVJM, Rua Vereador João Narciso, n.º 1380⁻Bairro Cachoeira, Unaí, Minas Gerais 38610-000, Brazil.
Department of Veterinary Medicine, Universidade Federal de Lavras-UFLA, Mail Box 3037, Lavras, Minas Gerais 37200-000, Brazil.
Nutrients. 2019 Apr 26;11(5):953. doi: 10.3390/nu11050953.
Resveratrol is an anti-inflammatory compound found in several foods. Periodontal disease (PD) is associated to other systemic diseases, and inflammation may be responsible for the association. Consequently, controlling inflammation not only may benefit oral health but also may assist with the management of other chronic inflammatory conditions. We aimed to investigate the effects of resveratrol administration on PD control in preclinical studies. A systematic search was performed for scientific articles using both electronic databases and a manual search using combinations of the following keywords: "resveratrol" OR "3,5,4'-trihydroxystilbene" AND "periodontal disease" OR "periodontitis" OR "gingivitis". Only in vivo original studies investigating resveratrol treatment on experimental animal models of PD were selected. A quality assessment of the studies was performed using the Animal Research Reporting In Vivo Experiment (ARRIVE) guidelines, and the risk of bias was assessed using the Syrcle tool. The search returned 570 articles, and 11 matched the inclusion criteria. A meta-analysis showed that resveratrol treatment attenuated alveolar bone loss (τ = 0.0041; 95% CI: -0.14; -0.04). The ARRIVE criteria reported a good quality of studies in general (mean score 28.5 ± 2.5). However, five Syrcle domains indicated a high risk of bias or did not present information clearly. We concluded that, in preclinical studies, resveratrol treatment prevented PD progression.
白藜芦醇是几种食物中发现的一种抗炎化合物。牙周病（PD）与其他全身性疾病有关，炎症可能是其相关的原因。因此，控制炎症不仅有益于口腔健康，还有助于管理其他慢性炎症性疾病。我们旨在调查白藜芦醇给药对牙周病控制的影响在临床前研究中。使用电子数据库和使用以下关键词的组合进行的手动搜索对科学文章进行了系统搜索：“白藜芦醇”或“3,5,4'-三羟基二苯乙烯”和“牙周病”或“牙周炎”或“牙龈炎”。仅选择了研究白藜芦醇对牙周病实验动物模型治疗的体内原始研究。使用动物研究报告体内实验（ARRIVE）指南对研究进行了质量评估，并使用 Syrcle 工具评估了偏倚风险。该搜索返回了 570 篇文章，其中 11 篇符合纳入标准。荟萃分析表明，白藜芦醇治疗可减轻牙槽骨丢失（τ=0.0041；95%CI：-0.14；-0.04）。ARRIVE 标准总体上报告了研究的高质量（平均得分为 28.5±2.5）。然而，五个 Syrcle 域表示存在高偏倚风险或未清楚地呈现信息。我们得出结论，在临床前研究中，白藜芦醇治疗可预防牙周病的进展。
