Szűcs Andrea, Kiss Anna Réka, Suhai Ferenc Imre, Tóth Attila, Gregor Zsófia, Horváth Márton, Czimbalmos Csilla, Csécs Ibolya, Dohy Zsófia, Szabó Liliána Erzsébet, Merkely Béla, Vágó Hajnalka
Heart and Vascular Center, Semmelweis University of Budapest, Budapest, Hungary.
Int J Cardiovasc Imaging. 2019 Sep;35(9):1683-1689. doi: 10.1007/s10554-019-01587-9. Epub 2019 Apr 29.
The acquisition of short-axis (SA) cine magnetic resonance (MR) images after the administration of contrast agent (CA) is a common, time-saving technique, but a decreased difference in the blood-myocardium contrast on these steady-state free precession (SSFP) cine scans could change the calculated parameters when using threshold-based papillary and trabecular muscle (PTM) quantification. We studied the effect of CA on the parameters calculated from pre- and post-CA SA cine images in noncompaction cardiomyopathy (NC-CMP) and healthy (H) participants using a threshold-based module. A total of 39 individuals (20 patients and 19 healthy) were included prospectively in this study. After the pre-CA SA images were acquired, i.v. gadobutrol (GA) or gadobenate dimeglumine (GD) (GA vs. GD: NC-CMP = 12 vs. 8; C = 12 vs. 7) was administered, and SA scans were repeated after two minutes. A threshold-based PTM software was used for postprocessing. Pre-CA and post-CA SA images were analyzed, and the parameters were compared in both the NC-CMP and H groups. The left ventricular volumes were significantly larger, while the left ventricular myocardial (LVmass) and trabecular mass (LVtrab) values were significantly smaller on the post-CA scans (NC-CMP: pre-CA vs. post-CA, EDV: 74.0 ± 13.6 vs. 81.1 ± 16.3 ml/m, ESV: 25.3 ± 7.3 vs. 30.1 ± 11.2 ml/m, LVmass-ED: 82.5 ± 17.5 vs. 75.7 ± 15.9 g/m, LVtrab-ED: 25.0 ± 6.6 vs. 18.9 ± 4.7 g/m; Healthy: preCA vs. post-CA, EDV: 69.7 ± 11.9 vs. 72.2 ± 10.7 ml/m, ESV: 22.6 ± 5.7 vs. 23.9 ± 6.3 ml/m, LVmass-ED: 71.3 ± 13.6 vs. 68.7 ± 13.9 g/m, LVtrab-ED: 19.4 ± 2.6 vs. 16.2 ± 3.0 g/m; p < 0.05). The decreased blood-myocardium contrast difference on post-CA SSFP SA cine images leads to altered cardiac parameters when using threshold-based software for evaluation.
注射造影剂（CA）后采集短轴（SA）电影磁共振（MR）图像是一种常见的省时技术，但在这些稳态自由进动（SSFP）电影扫描中，血液与心肌的对比度差异减小，可能会在使用基于阈值的乳头肌和小梁肌（PTM）定量方法时改变计算参数。我们使用基于阈值的模块，研究了CA对非致密性心肌病（NC-CMP）患者和健康（H）参与者在注射CA前后的SA电影图像计算参数的影响。本研究前瞻性纳入了39名个体（20例患者和19名健康者）。在采集注射CA前的SA图像后，静脉注射钆布醇（GA）或钆贝葡胺（GD）（GA与GD：NC-CMP组分别为12例和8例；健康组分别为12例和7例），两分钟后重复进行SA扫描。使用基于阈值的PTM软件进行后处理。分析注射CA前后的SA图像，并比较NC-CMP组和H组的参数。注射CA后的扫描中，左心室容积显著增大，而左心室心肌（LVmass）和小梁质量（LVtrab）值显著减小（NC-CMP组：注射CA前与注射CA后，舒张末期容积[EDV]：74.0±13.6 vs. 81.1±16.3 ml/m，收缩末期容积[ESV]：25.3±7.3 vs. 30.1±11.2 ml/m，舒张末期LVmass：82.5±17.5 vs. 75.7±15.9 g/m，舒张末期LVtrab：25.0±6.6 vs. 18.9±4.7 g/m；健康组：注射CA前与注射CA后，EDV：69.7±11.9 vs. 72.2±10.7 ml/m，ESV：22.6±5.7 vs. 23.9±6.3 ml/m，舒张末期LVmass：71.3±13.6 vs. 68.7±13.9 g/m，舒张末期LVtrab：19.4±2.6 vs. 16.2±3.0 g/m；p<0.05）。当使用基于阈值的软件进行评估时，注射CA后的SSFP SA电影图像上血液与心肌对比度差异的减小会导致心脏参数改变。
