NutRedOx Network (COST Action CA16112), Porto, Portugal.
Laboratory of Histology and Embryology, Institute of Biomedical Sciences Abel Salazar (ICBAS), Porto, Portugal.
Free Radic Res. 2019;53(sup1):1101-1112. doi: 10.1080/10715762.2019.1614176. Epub 2019 Oct 7.
Mediterranean diet (MD) is the most relevant nutritional aspect of the multisecular Mediterranean civilisation which includes wine as an element of health and wellbeing when consumed with moderation. Mediterranean meals provide food micronutrients which include polyphenols, especially resveratrol from grape and red wine. MD, also called Cretan diet, has been proven to prevent diseases including cardiovascular pathologies, cancer, and to prevent aging. Interestingly, the grape and more precisely in grape skin contains the highest concentration of RSV. In consequence, red wine is the most concentrated food source of RSV found in the human diet. This review topic deals to how efficient is RSV towards alterations during the aging process; obtained from recent data of clinical trials, preclinical studies, and cell culture approach; especially RSV protecting effect on brain aging of elderly; its role on the microglial cells playing a central role in the neuro-inflammation; and in its anti-inflammatory effects on ocular diseases.
地中海饮食（Mediterranean diet，MD）是拥有数千年历史的地中海文明中最重要的营养方面，其中包括将葡萄酒作为健康和幸福的元素适度饮用。地中海饮食提供食物微量营养素，包括多酚，尤其是来自葡萄和红酒的白藜芦醇(resveratrol)。MD 也被称为克里特饮食，已被证明可预防包括心血管病理、癌症在内的多种疾病，并可预防衰老。有趣的是，葡萄，更确切地说是葡萄皮，含有最高浓度的 RSV。因此，红酒是人类饮食中 RSV 浓度最高的食物来源。本综述主题涉及 RSV 在衰老过程中的改变效率；从临床试验、临床前研究和细胞培养方法的最新数据中获得；特别是 RSV 对老年人大脑衰老的保护作用；它在发挥核心作用的小胶质细胞中的作用在神经炎症中；以及其在眼部疾病中的抗炎作用。
