Southern California Hospital Heart Institute, 3831 Hughes Ave, Suite 105, Culver City, CA 90232.
Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030.
Nutr Res. 2020 Jun;78:11-26. doi: 10.1016/j.nutres.2020.03.002. Epub 2020 Mar 10.
The potential benefits of supplemental nutrients and dietary interventions against cardiovascular morbidity and mortality have been extensively investigated throughout the years. Numerous supplements claim cardioprotection and reduction of cardiovascular risk factors, but the roles of many supplements have not been determined. In the vast number of supplements on the market asserting cardioprotective effects, only 3 have been thoroughly evaluated and consistently reported as effective by our clinic patients. They have used supplements such as fish oil, multivitamins, and calcium, but many had not known of the benefits of resveratrol, curcumin, and nitric oxide as supplements for improving cardiovascular health. The cardioprotective effects of these dietary supplements in both animal models and humans have been explored with proposed mechanisms of action mostly attributed to antioxidant and anti-inflammatory properties. Resveratrol is one of the most studied polyphenols with established cardiovascular benefits. Preclinical studies have demonstrated these effects exerted via improved inflammatory markers, atherogenic profile, glucose metabolism, and endothelial function and are further supported by clinical trials. Curcumin has a well-established anti-inflammatory role by regulating numerous transcription factors and cytokines linked to inflammation. Inflammation is an underlying pathology in cardiovascular diseases, rendering curcumin a potential therapeutic compound. Similarly, nitric oxide supplementation has demonstrated cardiovascular benefits by normalizing blood pressure; enhancing blood flow; and reducing inflammation, immune dysfunction, and oxidative stress. A comprehensive review was performed evaluating the cardioprotective effects of these 3 dietary supplements with hope to provide updated information, promote further awareness of these supplements, and inspire future studies on their effects on cardiovascular health.
多年来，人们广泛研究了补充营养物质和饮食干预对心血管发病率和死亡率的潜在益处。许多补充剂声称具有心脏保护作用，并能降低心血管危险因素，但许多补充剂的作用尚未确定。在市场上声称具有心脏保护作用的大量补充剂中，只有 3 种经过我们诊所患者的彻底评估，并一致报告为有效。他们使用了鱼油、多种维生素和钙等补充剂，但许多人不知道白藜芦醇、姜黄素和一氧化氮作为改善心血管健康的补充剂的益处。这些膳食补充剂在动物模型和人类中的心脏保护作用及其作用机制已被探索，其作用机制主要归因于抗氧化和抗炎特性。白藜芦醇是研究最多的多酚之一，具有已确立的心血管益处。临床前研究表明，这些作用是通过改善炎症标志物、动脉粥样硬化特征、葡萄糖代谢和内皮功能来发挥的，临床试验进一步支持了这些作用。姜黄素通过调节与炎症相关的许多转录因子和细胞因子，发挥其抗炎作用。炎症是心血管疾病的潜在病理学，使姜黄素成为一种有潜力的治疗化合物。同样，一氧化氮补充通过正常化血压、增加血流量以及减少炎症、免疫功能障碍和氧化应激，具有心血管益处。我们进行了一项全面的综述，评估了这 3 种膳食补充剂的心脏保护作用，希望提供最新信息，促进对这些补充剂的进一步认识，并激发对它们对心血管健康影响的未来研究。
