Textile Engineering Department, Faculty of Engineering and Architecture, Kahramanmaras Sutcu Imam, University, Avşar Mah. BatıÇevreyolu Blv. No: 251/A, 46040, Kahramanmaras, Turkey.
Bioengineering Department, Institute of Science and Technology, Kahramanmaras Sutcu Imam University, Avşar Mah. BatıÇevreyolu Blv. No: 251/A, 46040, Kahramanmaras, Turkey.
J Nanosci Nanotechnol. 2019 Nov 1;19(11):7251-7260. doi: 10.1166/jnn.2019.16605.
In the present study, PCL (polycaprolactone) nanofibres were produced by the electrospinning method. The use of PCL electrospun biopolymer in biomedical applications has attracted considerable interest due to its chemical resistance, biodegradability, biocompatibility, and non-toxic characteristics. However, the hydrophobic nature of PCL polymer restricts the useage of PCL nanofibres for the cell adhesion and absorption. A hydrophilic and biocompatible PCL electrospun mat with a low water contact angle is an attractive strategy for development in tissue engineering and wound dressing. In this study, we demonstrate a feasible and simple method to produce hydrophilic PCL nanofibres for possible application in wound dressing. Chloroform/ethanol (EtOH) and chloroform/dimethylformamide (DMF) mixtures were used as two different solvent systems. The impact of the polymeric solution concentration, applied voltage, and solvent mixtures on the fibre surface morphology and water contact angle was investigated. Consequently, bead structures were observed at low concentrations but disappeared with increases in the concentration. It was observed that the size of beads decreased and the diameter of fibres increased with increasing voltage. The wettability of the webs changed from hydrophobic to hydrophilic with changes of the polymer concentration. The contact angle of the nanofibre mats decreased in both solvent systems as the concentration increased. The results showed that the lowest contact angle was obtained in 24% wt. PCL+chloroform/EtOH solution and was 68°. The highest contact angle was obtained in 4% wt. PCL+chloroform/EtOH solution and was 112°. Using this method, the surface hydrophilicity of the PCL nanofibres improved easily without any surface treatment.
在本研究中，通过静电纺丝法制备了聚己内酯（PCL）纳米纤维。由于其耐化学性、生物降解性、生物相容性和无毒特性，PCL 电纺生物聚合物在生物医学应用中引起了相当大的兴趣。然而，PCL 聚合物的疏水性限制了 PCL 纳米纤维在细胞黏附和吸收方面的应用。具有低水接触角的亲水和生物相容的 PCL 电纺垫是组织工程和伤口敷料开发的有吸引力的策略。在这项研究中，我们展示了一种可行且简单的方法来生产亲水 PCL 纳米纤维，以可能应用于伤口敷料。氯仿/乙醇（EtOH）和氯仿/二甲基甲酰胺（DMF）混合物被用作两种不同的溶剂体系。研究了聚合物溶液浓度、施加电压和溶剂混合物对纤维表面形貌和水接触角的影响。结果，在低浓度下观察到珠状结构，但随着浓度的增加而消失。观察到随着电压的增加，珠的尺寸减小，纤维的直径增加。随着聚合物浓度的变化，纤维网的润湿性从疏水性变为亲水性。在两种溶剂体系中，纳米纤维垫的接触角随着浓度的增加而降低。结果表明，在 24%wt.PCL+氯仿/EtOH 溶液中获得了最低的接触角为 68°，在 4%wt.PCL+氯仿/EtOH 溶液中获得了最高的接触角为 112°。使用这种方法，无需任何表面处理即可轻松提高 PCL 纳米纤维的表面亲水性。
