Hill J A, Haimovici F, Politch J A, Anderson D J
Fertil Steril. 1987 Mar;47(3):460-5. doi: 10.1016/s0015-0282(16)59056-6.
Experiments were conducted to evaluate the effects of supernatants from activated leukocyte cultures and purified lymphokine and monokine preparations on sperm motion. An automated semen analyzer was used to obtain accurate measurements of several parameters of sperm motion. Supernatants from activated peripheral blood leukocyte cultures significantly decreased sperm motility. In studies of effects of individual lymphokines and monokines, significant antimotility effects were observed when spermatozoa were incubated with the lymphokine gamma-interferon and the monokine tumor necrosis factor. Subnormal fertility may result from defective sperm function caused by lymphokines and monokines elaborated by activated lymphocytes and macrophages residing in the reproductive tracts of infertile men and women.
进行了实验以评估活化白细胞培养物的上清液以及纯化的淋巴因子和单核因子制剂对精子运动的影响。使用自动精液分析仪精确测量精子运动的几个参数。活化外周血白细胞培养物的上清液显著降低了精子活力。在对单个淋巴因子和单核因子作用的研究中，当精子与淋巴因子γ-干扰素和单核因子肿瘤坏死因子一起孵育时，观察到了显著的抗运动作用。生育力低下可能是由于居住在不育男性和女性生殖道中的活化淋巴细胞和巨噬细胞产生的淋巴因子和单核因子导致精子功能缺陷所致。
