ATP的2',3'-二醛：嗜热自养甲烷杆菌甲基还原酶系统A3组分的一种特异性、不可逆抑制剂。
2',3'-Dialdehyde of ATP: a specific, irreversible inhibitor of component A3 of the methylreductase system of Methanobacterium thermoautotrophicum.
作者信息
Rouvière P E, Wolfe R S
出版信息
J Bacteriol. 1987 Apr;169(4):1737-9. doi: 10.1128/jb.169.4.1737-1739.1987.
Abstract
Among 17 purine and ATP derivatives tested, 3 were found to totally inhibit the methyl coenzyme M methylreductase system of Methanobacterium thermoautotrophicum at a concentration of 5 mM; these derivatives were 8-azido-ATP, alpha, beta-thio-ADP and 2',3'-dialdehyde-ATP. 2',3'-Dialdehyde-ATP specifically and irreversibly bound to component A3 of the methylreductase system during ATP activation of the system.
摘要
在测试的17种嘌呤和ATP衍生物中，发现有3种在浓度为5 mM时能完全抑制嗜热自养甲烷杆菌的甲基辅酶M甲基还原酶系统；这些衍生物是8-叠氮基-ATP、α,β-硫代-ADP和2',3'-二醛基-ATP。在该系统的ATP激活过程中，2',3'-二醛基-ATP与甲基还原酶系统的A3组分特异性且不可逆地结合。
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