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1
Component A of the methyl coenzyme M methylreductase system of Methanobacterium: resolution into four components.甲烷杆菌甲基辅酶M甲基还原酶系统的组分A：分解为四个组分。
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2151-5. doi: 10.1073/pnas.80.8.2151.
2
Reductive activation of the methyl coenzyme M methylreductase system of Methanobacterium thermoautotrophicum delta H.嗜热自养甲烷杆菌δH甲基辅酶M甲基还原酶系统的还原激活作用
J Bacteriol. 1988 Sep;170(9):3946-52. doi: 10.1128/jb.170.9.3946-3952.1988.
3
The role of 7-mercaptoheptanoylthreonine phosphate in the methylcoenzyme M methylreductase system from Methanobacterium thermoautotrophicum.7-巯基庚酰苏氨酸磷酸在嗜热自养甲烷杆菌甲基辅酶M甲基还原酶系统中的作用。
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4
Role of component C in the methylreductase system of Methanobacterium.成分C在甲烷杆菌甲基还原酶系统中的作用。
J Biol Chem. 1980 Sep 25;255(18):8388-9.
5
Methyl coenzyme M reductase from Methanobacterium thermoautotrophicum. Resolution and properties of the components.嗜热自养甲烷杆菌的甲基辅酶M还原酶。各组分的拆分与性质
J Biol Chem. 1980 Mar 10;255(5):1891-5.
6
2',3'-Dialdehyde of ATP: a specific, irreversible inhibitor of component A3 of the methylreductase system of Methanobacterium thermoautotrophicum.ATP的2',3'-二醛：嗜热自养甲烷杆菌甲基还原酶系统A3组分的一种特异性、不可逆抑制剂。
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7
Component C of the methylcoenzyme M methylreductase system contains bound 7-mercaptoheptanoylthreonine phosphate (HS-HTP).甲基辅酶M甲基还原酶系统的组分C含有结合的7-巯基庚酰苏氨酸磷酸（HS-HTP）。
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Incorporation of coenzyme M into component C of methylcoenzyme M methylreductase during in vitro methanogenesis.在体外产甲烷过程中辅酶M掺入甲基辅酶M甲基还原酶的C组分中。
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9
ATP activation and properties of the methyl coenzyme M reductase system in Methanobacterium thermoautotrophicum.嗜热自养甲烷杆菌中甲基辅酶M还原酶系统的ATP激活及其特性
J Bacteriol. 1978 Sep;135(3):851-7. doi: 10.1128/jb.135.3.851-857.1978.
10
Methane formation from methyl-coenzyme M in a system containing methyl-coenzyme M reductase, component B and reduced cobalamin.在含有甲基辅酶M还原酶、组分B和还原型钴胺素的体系中，由甲基辅酶M生成甲烷。
Eur J Biochem. 1986 Apr 1;156(1):171-7. doi: 10.1111/j.1432-1033.1986.tb09563.x.

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1
Methyl (Alkyl)-Coenzyme M Reductases: Nickel F-430-Containing Enzymes Involved in Anaerobic Methane Formation and in Anaerobic Oxidation of Methane or of Short Chain Alkanes.甲基（烷基）辅酶 M 还原酶：含镍 F-430 的酶，参与厌氧甲烷形成以及甲烷或短链烷烃的厌氧氧化。
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Metabolic marker gene mining provides insight in global diversity and, coupled with targeted genome reconstruction, sheds further light on metabolic potential of the .代谢标记基因挖掘有助于洞察整体多样性，再结合靶向基因组重建，能进一步揭示[具体对象]的代谢潜力。
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In vivo activation of methyl-coenzyme M reductase by carbon monoxide.一氧化碳对甲基辅酶 M 还原酶的体内激活作用。
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Immunocytochemical localization of component C of the methylreductase system in Methanococcus voltae and Methanobacterium thermoautotrophicum.免疫细胞化学定位甲基还原酶系统成分 C 在 Methanococcus voltae 和 Methanobacterium thermoautotrophicum 中的位置。
Proc Natl Acad Sci U S A. 1986 Aug;83(16):5789-92. doi: 10.1073/pnas.83.16.5789.
5
Component A2 of methylcoenzyme M reductase system from Methanobacterium thermoautotrophicum delta H: nucleotide sequence and functional expression by Escherichia coli.嗜热自养甲烷杆菌δH甲基辅酶M还原酶系统的A2组分：核苷酸序列及在大肠杆菌中的功能表达
J Bacteriol. 1993 May;175(10):3195-203. doi: 10.1128/jb.175.10.3195-3203.1993.
6
Carbon monoxide-dependent methyl coenzyme M methylreductase in acetotrophic Methosarcina spp.嗜乙酸甲烷八叠球菌属中依赖一氧化碳的甲基辅酶M甲基还原酶
J Bacteriol. 1984 Nov;160(2):526-32. doi: 10.1128/jb.160.2.526-532.1984.
7
Methanogenesis: surprising molecules, microorganisms and ecosystems.甲烷生成：令人惊讶的分子、微生物与生态系统
Antonie Van Leeuwenhoek. 1984;50(5-6):557-67. doi: 10.1007/BF02386226.
8
Coenzymes of methanogenesis from hydrogen and carbon dioxide.由氢气和二氧化碳生成甲烷过程中的辅酶。
Antonie Van Leeuwenhoek. 1984;50(4):383-96. doi: 10.1007/BF00394653.
9
Formaldehyde oxidation and methanogenesis.甲醛氧化与甲烷生成。
J Bacteriol. 1984 May;158(2):721-6. doi: 10.1128/jb.158.2.721-726.1984.
10
Component A2 of the methylcoenzyme M methylreductase system from Methanobacterium thermoautotrophicum.嗜热自养甲烷杆菌甲基辅酶M甲基还原酶系统的A2组分。
J Bacteriol. 1985 Apr;162(1):61-6. doi: 10.1128/jb.162.1.61-66.1985.

本文引用的文献

1
Role of component C in the methylreductase system of Methanobacterium.成分C在甲烷杆菌甲基还原酶系统中的作用。
J Biol Chem. 1980 Sep 25;255(18):8388-9.
2
A procedure for anaerobic column chromatography employing an anaerobic Freter-type chamber.一种采用厌氧弗雷特型腔室的厌氧柱色谱法。
Anal Biochem. 1980 Jan 15;101(2):327-31. doi: 10.1016/0003-2697(80)90195-5.
3
Purification and properties of an 8-hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum.嗜热自养甲烷杆菌中8-羟基-5-脱氮黄素还原氢化酶的纯化及性质
J Biol Chem. 1982 Apr 10;257(7):3385-8.
4
Nickel-containing factor F430: chromophore of the methylreductase of Methanobacterium.含镍因子F430：甲烷杆菌甲基还原酶的发色团。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3707-10. doi: 10.1073/pnas.79.12.3707.
5
Presence of coenzyme M derivatives in the prosthetic group (coenzyme MF430) of methylcoenzyme M reductase from Methanobacterium thermoautotrophicum.嗜热自养甲烷杆菌甲基辅酶M还原酶的辅基（辅酶MF430）中辅酶M衍生物的存在。
Biochem Biophys Res Commun. 1982 Sep 30;108(2):495-503. doi: 10.1016/0006-291x(82)90856-7.
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Component C of the methylreductase system of Methanobacterium.甲烷杆菌甲基还原酶系统的C组分。
J Biol Chem. 1981 May 10;256(9):4259-62.
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Methyl coenzyme M reductase from Methanobacterium thermoautotrophicum. Resolution and properties of the components.嗜热自养甲烷杆菌的甲基辅酶M还原酶。各组分的拆分与性质
J Biol Chem. 1980 Mar 10;255(5):1891-5.
8
A selenium-containing hydrogenase from Methanococcus vannielii. Identification of the selenium moiety as a selenocysteine residue.来自万氏甲烷球菌的一种含硒氢化酶。将硒部分鉴定为硒代半胱氨酸残基。
J Biol Chem. 1982 Jul 25;257(14):7926-9.
9
Membrane-bound flavin adenine dinucleotide in Methanobacterium Bryantii.布氏甲烷杆菌中的膜结合黄素腺嘌呤二核苷酸
Biochem Biophys Res Commun. 1981 May 15;100(1):240-6. doi: 10.1016/s0006-291x(81)80088-5.
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Hydrogen ion buffers for biological research.用于生物学研究的氢离子缓冲剂。
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甲烷杆菌甲基辅酶M甲基还原酶系统的组分A：分解为四个组分。

Component A of the methyl coenzyme M methylreductase system of Methanobacterium: resolution into four components.

作者信息

Nagle D P, Wolfe R S

出版信息

Proc Natl Acad Sci U S A. 1983 Apr;80(8):2151-5. doi: 10.1073/pnas.80.8.2151.

DOI:10.1073/pnas.80.8.2151
PMID:6403944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC393775/
Abstract

Component A, the oxygen-sensitive protein fraction of the methyl coenzyme M methylreductase system of Methanobacterium thermoautotrophicum, has been stabilized and resolved into three protein fractions and one cofactor that are required to reconstitute component A activity. Component A1 is oxygen-stable and contains hydrogen-dependent deazaflavin (coenzyme F420)-reducing activity. Component A2 is acidic; components A2 and A3 are oxygen sensitive. The specific functions of each component in methyl group reduction are unknown. Resolution of component A revealed a new cofactor requirement of the methylreductase system for FAD. Hydrogen-dependent reduction of methyl coenzyme M to methane and coenzyme M, the terminal step of CO2 reduction by methanogenic bacteria, requires protein components A1, A2, A3, and C in addition to component B, FAD, ATP, and Mg2+.

摘要

组分A是嗜热自养甲烷杆菌甲基辅酶M甲基还原酶系统中对氧敏感的蛋白质部分，现已得到稳定，并分解为三个蛋白质部分和一个辅因子，这些是重建组分A活性所必需的。组分A1对氧稳定，具有依赖氢的脱氮黄素（辅酶F420）还原活性。组分A2呈酸性；组分A2和A3对氧敏感。各组分在甲基还原中的具体功能尚不清楚。组分A的分解揭示了甲基还原酶系统对FAD有新的辅因子需求。嗜甲烷菌将二氧化碳还原的最后一步，即依赖氢将甲基辅酶M还原为甲烷和辅酶M，除了组分B、FAD、ATP和Mg2+外，还需要蛋白质组分A1、A2、A3和C。