Ferguson M, Wachmann B, Needy C F, Fitzgerald E A
J Biol Stand. 1987 Jan;15(1):73-7. doi: 10.1016/0092-1157(87)90018-7.
Antigenic differences between rabies virus strains used for vaccine manufacture can be demonstrated using monoclonal antibodies. We have shown that these differences are sufficiently large to affect the potency values of vaccines measured in single radial immunodiffusion (SRD) assays if the reference and test vaccines are antigenically heterologous. The production of reagents for use in SRD assays for each strain of rabies virus should be considered.
用于疫苗生产的狂犬病病毒株之间的抗原差异可以通过单克隆抗体来证明。我们已经表明，如果参考疫苗和测试疫苗在抗原性上是异源的，那么这些差异足够大，足以影响在单向辐射免疫扩散（SRD）试验中测得的疫苗效价。应该考虑为每株狂犬病病毒生产用于SRD试验的试剂。
