林加毒素A的两阶段小鼠皮肤致癌研究。
A two-stage mouse skin carcinogenesis study of lyngbyatoxin A.
作者信息
Fujiki H, Suganuma M, Hakii H, Bartolini G, Moore R E, Takayama S, Sugimura T
出版信息
J Cancer Res Clin Oncol. 1984;108(1):174-6. doi: 10.1007/BF00390993.
Abstract
A strong skin irritant, lyngbyatoxin A, isolated from the marine blue-green alga Lyngbya majuscula is structurally related to teleocidin. Since lyngbyatoxin A satisfied our short-term screening tests for possible tumor promoters, viz. irritation of mouse ear, induction of ornithine decarboxylase (ODC) in mouse skin, and adhesion of human promyelocytic leukemia cells (HL-60), a two-stage carcinogenesis experiment was carried out. Tumor incidences in the groups treated with 7,12-dimethylbenz(a)anthracene (DMBA) plus lyngbyatoxin A and with DMBA plus 12-O-tetradecanoylphorbol-13-acetate (TPA) were 86.7% and 93.3% in week 30, respectively. The average number of tumors per mouse was 3.7 in the former group and 10.5 in the latter group. This paper reports for the first time the potent tumor-promoting activity of lyngbyatoxin A and also the histological examination of tumors.
摘要
从海洋蓝绿藻巨大鞘丝藻中分离出的一种强皮肤刺激物——林加毒素A，在结构上与杀鱼菌素有关。由于林加毒素A符合我们对可能的肿瘤促进剂的短期筛选试验，即对小鼠耳朵的刺激、在小鼠皮肤中诱导鸟氨酸脱羧酶（ODC）以及人早幼粒细胞白血病细胞（HL-60）的黏附，因此进行了两阶段致癌实验。在第30周时，用7,12-二甲基苯并(a)蒽（DMBA）加林加毒素A处理的组和用DMBA加12-O-十四酰佛波醇-13-乙酸酯（TPA）处理的组的肿瘤发生率分别为86.7%和93.3%。前一组每只小鼠的平均肿瘤数为3.7个，后一组为10.5个。本文首次报道了林加毒素A的强肿瘤促进活性以及肿瘤的组织学检查。
相似文献
1
A two-stage mouse skin carcinogenesis study of lyngbyatoxin A.林加毒素A的两阶段小鼠皮肤致癌研究。
J Cancer Res Clin Oncol. 1984;108(1):174-6. doi: 10.1007/BF00390993.
2
Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis.毒胡萝卜素是一种组胺促分泌剂，在小鼠皮肤两阶段致癌过程中是一种非12 - O -十四烷酰佛波醇-13 -乙酸酯（TPA）型肿瘤促进剂。
J Cancer Res Clin Oncol. 1986;111(3):177-81. doi: 10.1007/BF00389230.
3
Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.吲哚生物碱：二氢远侧素B、远侧素和林加毒素A作为一类新型肿瘤促进剂的成员。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3872-6. doi: 10.1073/pnas.78.6.3872.
4
Sarcophytols A and B inhibit tumor promotion by teleocidin in two-stage carcinogenesis in mouse skin.肉质珊瑚醇A和B在小鼠皮肤两阶段致癌过程中抑制远藤菌素的促肿瘤作用。
J Cancer Res Clin Oncol. 1989;115(1):25-8. doi: 10.1007/BF00391595.
5
Teleocidin, lyngbyatoxin A and their hydrogenated derivatives, possible tumor promoters, induce terminal differentiation in HL-60 cells.远侧素、林加毒素A及其氢化衍生物可能是肿瘤促进剂，可诱导HL-60细胞发生终末分化。
Cancer Lett. 1981 May;12(4):271-7. doi: 10.1016/0304-3835(81)90168-3.
6
Tumor promoting activity of teleocidin in skin and forestomach of mice initiated transplacentally with 7,12-dimethylbenz(a)anthracene.用7,12-二甲基苯并(a)蒽经胎盘引发的小鼠皮肤和前胃中杀鱼菌素的促肿瘤活性。
J Cancer Res Clin Oncol. 1987;113(2):123-5. doi: 10.1007/BF00391432.
7
Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.通过在妊娠第6至20天用7,12 - 二甲基苯并(a)蒽对怀孕小鼠进行全身启动，并在F1代出生后用佛波酯12 - 十四酰佛波醇-13 - 乙酸酯进行促进，诱导两阶段皮肤癌发生。
J Cancer Res Clin Oncol. 1980;98(3):267-75. doi: 10.1007/BF00410789.
8
Cepharanthine inhibits two-stage tumor promotion by 12-O-tetradecanoylphorbol 13-acetate and mezerein on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.千金藤素抑制由12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯和斑蝥素对经7,12 - 二甲基苯并[a]蒽引发的小鼠皮肤肿瘤形成的两阶段肿瘤促进作用。
J Cancer Res Clin Oncol. 1991;117(5):421-4. doi: 10.1007/BF01612761.
9
Biological assays for irritant, tumor-initiating and tumor-promoting activities. II. Standardized initiation/promotion protocol and semiquantitative estimation of promoting (or initiating) potencies in skin of NMRI mice.刺激性、肿瘤启动和肿瘤促进活性的生物学测定。II. 标准化的启动/促进方案以及NMRI小鼠皮肤中促进（或启动）效力的半定量评估。
J Cancer Res Clin Oncol. 1989;115(6):516-24. doi: 10.1007/BF00391351.
10
Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis.
Carcinogenesis. 1986 May;7(5):707-10. doi: 10.1093/carcin/7.5.707.
引用本文的文献
1
The Chemistry of Phytoplankton.浮游植物的化学
Chem Rev. 2024 Dec 11;124(23):13099-13177. doi: 10.1021/acs.chemrev.4c00177. Epub 2024 Nov 21.
2
Structural insights into C1-ligand interactions: Filling the gaps by in silico methods.结构洞察 C1 配体相互作用：通过计算机模拟方法填补空白。
Adv Biol Regul. 2021 Jan;79:100784. doi: 10.1016/j.jbior.2020.100784. Epub 2021 Jan 18.
3
Cyanobacterial Toxins of the Laurentian Great Lakes, Their Toxicological Effects, and Numerical Limits in Drinking Water.劳伦琴五大湖的蓝藻毒素、其毒理学效应及饮用水中的数值限值
Mar Drugs. 2017 Jun 2;15(6):160. doi: 10.3390/md15060160.
4
Bloom Dynamics of Cyanobacteria and Their Toxins: Environmental Health Impacts and Mitigation Strategies.蓝藻及其毒素的爆发动态：对环境健康的影响及缓解策略
Front Microbiol. 2015 Nov 17;6:1254. doi: 10.3389/fmicb.2015.01254. eCollection 2015.
5
Is protein phosphatase inhibition responsible for the toxic effects of okadaic Acid in animals?蛋白磷酸酶抑制是否是冈田酸在动物体内产生毒性作用的原因？
Toxins (Basel). 2013 Feb 4;5(2):267-85. doi: 10.3390/toxins5020267.
6
Cyclic peptides and depsipeptides from cyanobacteria: a review.来自蓝细菌的环肽和缩肽：综述
J Ind Microbiol. 1996 Feb;16(2):134-43. doi: 10.1007/BF01570074.
7
Effect of biological toxins on gap-junctional intercellular communication in Chinese hamster V79 cells.生物毒素对中国仓鼠V79细胞间隙连接细胞间通讯的影响。
Cell Biol Toxicol. 1987 Mar;3(1):1-15. doi: 10.1007/BF00117821.
本文引用的文献
1
Stimulation of prostaglandin production and choline turnover in HeLa cells by lyngbyatoxin A and dihydroteleocidin B.
Biochem Biophys Res Commun. 1981 Sep 16;102(1):100-7. doi: 10.1016/0006-291x(81)91494-7.
2
Inhibition of specific binding of [3H]phorbol-12,13-dipropionate to an epidermal fraction by certain irritants and irritant promoters of mouse skin.某些小鼠皮肤刺激物和刺激性促癌剂对[3H]佛波醇-12,13-二丙酸酯与表皮部分特异性结合的抑制作用。
Carcinogenesis. 1983;4(1):77-81. doi: 10.1093/carcin/4.1.77.
3
Potent tumor promoters other than phorbol ester and their significance.除佛波酯之外的强效肿瘤启动子及其意义。
Gan. 1982 Aug;73(4):499-507.
4
Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis.链霉菌产生的杀鱼菌素是小鼠皮肤癌发生的强效促进剂。
Carcinogenesis. 1982;3(8):895-8. doi: 10.1093/carcin/3.8.895.
5
Teleocidin: new naturally occurring tumor promoter.
Carcinog Compr Surv. 1982;7:69-73.
6
Teleocidin, lyngbyatoxin A and their hydrogenated derivatives, possible tumor promoters, induce terminal differentiation in HL-60 cells.远侧素、林加毒素A及其氢化衍生物可能是肿瘤促进剂，可诱导HL-60细胞发生终末分化。
Cancer Lett. 1981 May;12(4):271-7. doi: 10.1016/0304-3835(81)90168-3.
7
Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.吲哚生物碱：二氢远侧素B、远侧素和林加毒素A作为一类新型肿瘤促进剂的成员。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3872-6. doi: 10.1073/pnas.78.6.3872.
8
New classes of environmental tumor promoters: indole alkaloids and polyacetates.新型环境肿瘤促进剂：吲哚生物碱和聚乙酸酯。
Environ Health Perspect. 1983 Apr;50:85-90. doi: 10.1289/ehp.835085.
9
Enhanced incorporation of radioactive inorganic phosphate into phospholipids of HeLa cells by tumor promoters.肿瘤启动子增强放射性无机磷酸盐掺入HeLa细胞磷脂的过程。
Carcinogenesis. 1983;4(1):107-10. doi: 10.1093/carcin/4.1.107.
10
Activation of the EBV-cycle and aggregation of human blood lymphocytes by the tumor promoters teleocidin, lyngbyatoxin A, aplysiatoxin and debromoaplysiatoxin.肿瘤启动子teleocidin、lyngbyatoxin A、海兔毒素和去溴海兔毒素对EB病毒周期的激活作用及人血淋巴细胞的聚集作用。
Int J Cancer. 1983 Jan 15;31(1):7-11. doi: 10.1002/ijc.2910310103.
Zotero 插件