林加毒素A的两阶段小鼠皮肤致癌研究。
A two-stage mouse skin carcinogenesis study of lyngbyatoxin A.
作者信息
Fujiki H, Suganuma M, Hakii H, Bartolini G, Moore R E, Takayama S, Sugimura T
出版信息
J Cancer Res Clin Oncol. 1984;108(1):174-6. doi: 10.1007/BF00390993.
Abstract
A strong skin irritant, lyngbyatoxin A, isolated from the marine blue-green alga Lyngbya majuscula is structurally related to teleocidin. Since lyngbyatoxin A satisfied our short-term screening tests for possible tumor promoters, viz. irritation of mouse ear, induction of ornithine decarboxylase (ODC) in mouse skin, and adhesion of human promyelocytic leukemia cells (HL-60), a two-stage carcinogenesis experiment was carried out. Tumor incidences in the groups treated with 7,12-dimethylbenz(a)anthracene (DMBA) plus lyngbyatoxin A and with DMBA plus 12-O-tetradecanoylphorbol-13-acetate (TPA) were 86.7% and 93.3% in week 30, respectively. The average number of tumors per mouse was 3.7 in the former group and 10.5 in the latter group. This paper reports for the first time the potent tumor-promoting activity of lyngbyatoxin A and also the histological examination of tumors.
摘要
从海洋蓝绿藻巨大鞘丝藻中分离出的一种强皮肤刺激物——林加毒素A，在结构上与杀鱼菌素有关。由于林加毒素A符合我们对可能的肿瘤促进剂的短期筛选试验，即对小鼠耳朵的刺激、在小鼠皮肤中诱导鸟氨酸脱羧酶（ODC）以及人早幼粒细胞白血病细胞（HL-60）的黏附，因此进行了两阶段致癌实验。在第30周时，用7,12-二甲基苯并(a)蒽（DMBA）加林加毒素A处理的组和用DMBA加12-O-十四酰佛波醇-13-乙酸酯（TPA）处理的组的肿瘤发生率分别为86.7%和93.3%。前一组每只小鼠的平均肿瘤数为3.7个，后一组为10.5个。本文首次报道了林加毒素A的强肿瘤促进活性以及肿瘤的组织学检查。
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