Department of Dermatology, University of Minnesota, Minneapolis.
Dermatitis. 2019 May/Jun;30(3):207-212. doi: 10.1097/DER.0000000000000478.
Formaldehyde is a common preservative and strong sensitizer.
The aim of the study was to evaluate the release of formaldehyde from baby/toddler wet wipes using the chromotropic acid method (CAM).
An online search of best-selling baby wipes was conducted. None declared formaldehyde or formaldehyde-releasing preservatives. Standard CAM procedures were used: a 1 × 1-in square of fresh wipe was placed in a bottle with an open vial of 4 mg/1 mL of chromotropic acid and sulfuric acid solution, sealed, and stored for 48 hours. Formalin and water served as controls. A blinded investigator graded color change (negative, indeterminate, mild, moderate, or strong). For quality control, 20% of all samples as well as all positives were retested.
Fifty-one popular and highly reviewed baby and toddler wet wipe products were tested using CAM. Twelve wipes (24%) released formaldehyde (8 mild, 4 moderate/strong). Chromotropic acid method testing of 9 wipes (18%) was indeterminate and 30 (59%) were negative.
Almost one quarter of baby/toddler wet wipes released formaldehyde when evaluated with CAM. Patients and clinicians should be aware of this potentially undeclared source of this common allergen.
甲醛是一种常见的防腐剂和强致敏剂。
本研究旨在使用变色酸法（CAM）评估婴儿/幼儿湿巾中甲醛的释放情况。
对畅销的婴儿湿巾进行了在线搜索。没有一款宣称含有甲醛或释放甲醛的防腐剂。标准 CAM 程序如下：将 1×1 英寸见方的新鲜湿巾放入一个瓶子中，瓶子中装有 4mg/1mL 的变色酸和硫酸溶液，密封并储存 48 小时。福尔马林和水作为对照。一位盲法研究员对颜色变化（阴性、不确定、轻度、中度或强）进行分级。为了质量控制，所有样品的 20%以及所有阳性样品均进行了复测。
使用 CAM 对 51 种流行且评价较高的婴儿和幼儿湿巾产品进行了测试。12 种湿巾（24%）释放出甲醛（8 种轻度，4 种中度/强）。CAM 测试的 9 种湿巾（18%）结果不确定，30 种（59%）结果为阴性。
当使用 CAM 评估时，近四分之一的婴儿/幼儿湿巾释放出甲醛。患者和临床医生应注意这种潜在的未申报的常见过敏原来源。
