Department of Dermatology, University of Minnesota, Minneapolis.
Dermatitis. 2019 Jan/Feb;30(1):67-73. doi: 10.1097/DER.0000000000000434.
Preservatives such as formaldehyde and formaldehyde releasers (F/FRs) are found in personal care products. Studies from Europe and Israel have indicated that products with undeclared F/FRs on product labels may have detectable levels of formaldehyde.
The aim of the study was to determine the presence of formaldehyde in samples of US personal care products.
Fifty-four baby and adult products were tested with the chromotropic acid method. A blinded investigator graded the color change as mild, moderate, or strong.
All 8 products declaring F/FRs resulted in a deep purple color change, indicating a strong reaction. Of the 46 products with undeclared F/FRs, 4 (8.6%) were found to release formaldehyde. All 4 resulted in a light purple color change, indicating a mild reaction.
Overall, 4 of 54 products (7.4%) had label information, which did not match chromotropic acid method testing results. Clinicians and formaldehyde-allergic individuals should be aware of the limitations of product ingredient labeling in managing allergic contact dermatitis to formaldehyde.
甲醛和甲醛释放剂（F/FRs）等防腐剂存在于个人护理产品中。来自欧洲和以色列的研究表明，产品标签上未申报 F/FRs 的产品可能含有可检测水平的甲醛。
本研究旨在确定美国个人护理产品中是否存在甲醛。
用变色酸法对 54 种婴儿和成人产品进行了测试。一位盲法研究员将颜色变化评为轻度、中度或强。
所有 8 种宣称含有 F/FRs 的产品均导致深紫色变色，表明反应强烈。在 46 种未申报 F/FRs 的产品中，有 4 种（8.6%）释放出甲醛。所有 4 种产品均导致浅紫色变色，表明反应轻微。
总体而言，54 种产品中有 4 种（7.4%）的标签信息与变色酸法检测结果不匹配。临床医生和对甲醛过敏的个体应意识到在管理对甲醛的过敏性接触性皮炎时，产品成分标签的局限性。
