Chemistry for Health/Bioanalytical Sciences Research Group, Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK.
Department of Chemistry, University of Loughborough, Epinal Way, Loughborough, LE11 3TU, UK.
Anal Chim Acta. 2019 Aug 27;1067:11-30. doi: 10.1016/j.aca.2019.02.026. Epub 2019 Feb 23.
The employment of spectroscopically-resolved NMR techniques as analytical probes have previously been both prohibitively expensive and logistically challenging in view of the large sizes of high-field facilities. However, with recent advances in the miniaturisation of magnetic resonance technology, low-field, cryogen-free "benchtop" NMR instruments are seeing wider use. Indeed, these miniaturised spectrometers are utilised in areas ranging from food and agricultural analyses, through to human biofluid assays and disease monitoring. Therefore, it is both intrinsically timely and important to highlight current applications of this analytical strategy, and also provide an outlook for the future, where this approach may be applied to a wider range of analytical problems, both qualitatively and quantitatively.
以往，由于高场设施体积庞大，因此采用光谱分辨 NMR 技术作为分析探针既非常昂贵，又在物流方面具有挑战性。然而，随着磁共振技术的小型化最近取得进展，低场、无液氦“台式”NMR 仪器的应用越来越广泛。实际上，这些小型化的光谱仪不仅应用于食品和农业分析等领域，还应用于人体生物流体分析和疾病监测等领域。因此，及时重点介绍这种分析策略的当前应用，并展望未来这种方法可能在定性和定量方面应用于更广泛的分析问题，这两方面都非常重要。
