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一种新型草本金属纳米药物具有通过氧化损伤产生抗菌和抗癌活性的潜力。

A novel herbometallic nanodrug has the potential for antibacterial and anticancer activity through oxidative damage.

机构信息

Centre for Healthcare Science & Technology, Indian Institute of Engineering Science & Technology, Shibpur, Howrah 711103, West Bengal, India.

Department of Life Science & Bio-technology, Jadavpur University, Kolkata 700032, West Bengal, India.

出版信息

Nanomedicine (Lond). 2019 May;14(9):1173-1189. doi: 10.2217/nnm-2018-0187. Epub 2019 May 3.

Abstract

Preparation of a herbometallic nano-drug, Rasa Manikya nanoparticle (RMNP) and investigation of its antimicrobial, and anticancer activity. Physicochemical characterizations of RMNP were performed using different analytical methods. The antimicrobial and anticancer potential of RMNPs were assessed by an cellular assay. Bacterial cell wall lysis was observed by field emission scanning electron microscopy and mitochondrial metabolism alteration factor was measured standard method. Physicochemical analysis confirmed that RMNP was rich in mineral constituents. Synergistic effect of RMNPs enhanced lysis of bacterial peptidoglycan layers and impaired cellular redox balance, GSH/NADPH level followed by induction of cell apoptosis. The present study confirms that RMNP can be used as a dual therapeutic option for combating drug-resistant microbial strains and breast cancer.

摘要

草药金属纳米药物 Rasa Manikya 纳米颗粒(RMNP)的制备及其抗菌和抗癌活性的研究。采用不同的分析方法对 RMNP 的物理化学性质进行了表征。通过细胞测定法评估了 RMNPs 的抗菌和抗癌潜力。场发射扫描电子显微镜观察到细菌细胞壁裂解,通过标准方法测量线粒体代谢改变因子。物理化学分析证实 RMNP 富含矿物质成分。RMNPs 的协同作用增强了细菌肽聚糖层的裂解,并损害了细胞氧化还原平衡、GSH/NADPH 水平,随后诱导细胞凋亡。本研究证实 RMNP 可作为对抗耐药微生物菌株和乳腺癌的双重治疗选择。

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