来自深海海绵 Pachastrella scrobiculosa 的 Scrobiculosides A 和 B。

Scrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa.

机构信息

Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.

Center for Marine and Coastal Studies (CEMACS), Universiti Sains Malaysia (USM), 11800, Nibong Tebal, Penang, Malaysia.

出版信息

J Nat Med. 2019 Sep;73(4):814-819. doi: 10.1007/s11418-019-01315-6. Epub 2019 May 3.

DOI:10.1007/s11418-019-01315-6

PMID:31054009

Abstract

Two new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa, collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosides A and B feature a vinylic cyclopropane and a ∆ exomethylene on the side chains, respectively. Both saponins have a common sugar moiety composed of β-D-galactopyranosyl-(1 → 2)-6-acetyl-β-D-glucopyranoside, with the exception of an acetyl group on C6″ in scrobiculoside A. Scrobiculoside A exhibited cytotoxicity against HL-60 and P388 cells, with IC values of 52 and 61 μM, respectively.

摘要

从日本三浦半岛 200 米深处采集的深海海绵 Pachastrella scrobiculosa 中分离得到两种新的甾体皂苷，即 scrobiculoside A 和 B。scrobiculoside A 和 B 的苷元在侧链上分别具有一个乙烯基环丙烷和一个 ∆ exo 亚甲基。这两种皂苷都有一个共同的糖部分，由β-D-半乳糖吡喃糖苷-(1→2)-6-乙酰-β-D-吡喃葡萄糖苷组成，不同之处在于 scrobiculoside A 在 C6″上有一个乙酰基。Scrobiculoside A 对 HL-60 和 P388 细胞表现出细胞毒性，IC 值分别为 52 和 61 μM。