术前绝对淋巴细胞、单核细胞和中性粒细胞计数作为胃癌患者预后指标的评分。
Score of the preoperative absolute number of lymphocytes, monocytes, and neutrophils as a prognostic indicator for patients with gastric cancer.
机构信息
Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, School of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan.
出版信息
Surg Today. 2019 Oct;49(10):850-858. doi: 10.1007/s00595-019-01817-6. Epub 2019 May 6.
PURPOSE
The association between the preoperative absolute neutrophil count (NC), lymphocyte count (LC), and monocyte count (MC) in the peripheral blood and the prognosis of gastric cancer (GC) patients has not been investigated widely.
METHODS
We enrolled 445 patients who underwent surgery for GC between January, 2005 and April, 2013 to analyze the correlations among NC, LC, and MC and their prognoses.
RESULTS
Based on cut-off values calculated by ROC analysis, patients were sub grouped as having: NC ≥ 4477 (NC), NC < 4477 (NC); and as LC ≥ 1447 (LC), LC < 1447 (LC); and as MC ≥ 658.5 (MC), MC < 658.5 (MC). Each group was assigned as follows; NC group = 1, NC group = 0, LC group = 0, LC group = 1, MC group = 1, MC group = 0, and the sum of each score was defined as the lymphocyte-monocyte-neutrophil score (LMN score). The overall 5-year survival rates were 89%, 74%, 57.8%, and 53.3% for LMN scores of 0, 1, 2, and 3, respectively (P = 0.0004). Multivariate analysis indicated that the LMN score was an independent prognostic indicator.
CONCLUSIONS
The combination of preoperative NC, LC, and MC appears to be a useful indicator of GC prognosis.
目的
术前外周血中性粒细胞计数（NC）、淋巴细胞计数（LC）和单核细胞计数（MC）与胃癌（GC）患者预后的关系尚未得到广泛研究。
方法
我们纳入了 2005 年 1 月至 2013 年 4 月期间接受 GC 手术的 445 例患者，以分析 NC、LC 和 MC 之间的相关性及其预后。
结果
根据 ROC 分析计算的截断值，患者被分为 NC≥4477（NC）和 NC<4477（NC）；LC≥1447（LC）和 LC<1447（LC）；MC≥658.5（MC）和 MC<658.5（MC）。每组分别赋值为：NC 组=1，NC 组=0，LC 组=0，LC 组=1，MC 组=1，MC 组=0，每个评分的总和定义为淋巴细胞-单核细胞-中性粒细胞评分（LMN 评分）。LMN 评分为 0、1、2 和 3 的总 5 年生存率分别为 89%、74%、57.8%和 53.3%（P=0.0004）。多因素分析表明，LMN 评分是独立的预后指标。
结论
术前 NC、LC 和 MC 的组合似乎是 GC 预后的有用指标。
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