1,2-双(硼酸酯)的位点选择性单氧化
Site-Selective Mono-Oxidation of 1,2-Bis(boronates).
机构信息
Department of Chemistry, Merkert Chemistry Center , Boston College , Chestnut Hill , Massachusetts 02467 , United States.
出版信息
Org Lett. 2019 May 17;21(10):3760-3763. doi: 10.1021/acs.orglett.9b01204. Epub 2019 May 8.
Abstract
Site-selective oxidation of vicinal bis(boronates) is accomplished through the use of trimethylamine N-oxide in 1-butanol solvent. The reaction occurs with good efficiency and selectivity across a range of substrates, providing 2-hydro-1-boronic esters which are shown to be versatile intermediates in the synthesis of chiral building blocks.
摘要
通过在 1-丁醇溶剂中使用三甲基氧化胺，可以实现邻位双（硼酸酯）的选择性氧化。该反应在一系列底物中具有良好的效率和选择性，提供了 2-羟基-1-硼酸酯，它们被证明是手性砌块合成中的多功能中间体。
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