Karsenti David, Tharsis Gaëlle, Zeitoun Jean-David, Denis Philippe, Perrot Bastien, Coelho Jessica, Bellaiche Guy, Charbit Lionel, Hakoune Jean-Jacques, Doumet Sylva, Sion-Rohart Elena, Cavicchi Maryan, Zago Jacqueline
a Digestive Endoscopy Unit , Pôle Digestif Paris Bercy, Clinique de Paris-Bercy , Charenton-le-Pont , France.
b Pathology Unit , 29 rue du Colisée, Paris , France.
Scand J Gastroenterol. 2019 Apr;54(4):499-505. doi: 10.1080/00365521.2019.1599418. Epub 2019 May 8.
Endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) has been proposed to obtain high-quality tissue samples for pancreatic tumors. We performed an observational study to compare EUS-FNB with a 20-gauge Procore® needle versus a 22-gauge Acquire® needle. Our primary endpoint was the quantity of the obtained tissue, as defined by the mean cumulative length of tissue core biopsies per needle pass. Sixty-eight EUS-FNB were consecutively performed on patients with a pancreatic mass. The choice of needle depended on availability at the time of admission: 34 punctures were performed with each needle. Histological material was studied in a blinded manner with respect to the needle, and the cumulative length of tissue core biopsies per needle pass was determined. Intraobserver and interobserver variability of this criterion was then evaluated. There were no between-group differences. Histological diagnosis was achieved and core biopsy specimens were obtained in 28 out of 34 patients (82%) in the 20-gauge Procore® group and in 33 out of 34 patients (97%) in the 22-gauge Acquire® group ( = .1). The mean cumulative length of tissue core biopsies per needle pass was significantly higher with the 22-gauge Acquire® needle with 8.2 ± 4.2 mm versus 4.2 ± 3.8 mm for the 20-gauge Procore® needle ( < .01). No intra and inter-observer variability of this criterion was observed. Our results suggest significant differences, with a mean cumulative length of tissue core biopsies per needle pass significantly higher with the 22-gauge Acquire® needle. This simple criterion seems reliable and reproducible.
内镜超声引导下细针穿刺活检（EUS-FNB）已被用于获取高质量的胰腺肿瘤组织样本。我们进行了一项观察性研究，比较了使用20G Procore®针与22G Acquire®针进行EUS-FNB的情况。我们的主要终点是所获取组织的量，以每次穿刺活检所取组织条的平均累积长度来定义。对68例胰腺肿块患者连续进行了EUS-FNB。穿刺针的选择取决于入院时的可获得性：每种穿刺针各进行了34次穿刺。对组织学材料进行盲法研究，不考虑使用的穿刺针，并确定每次穿刺活检所取组织条的累积长度。然后评估该标准在观察者内和观察者间的变异性。两组之间没有差异。20G Procore®组34例患者中有28例（82%）获得了组织学诊断并取得了活检标本，22G Acquire®组34例患者中有33例（97%）获得了组织学诊断并取得了活检标本（P = 0.1）。22G Acquire®针每次穿刺活检所取组织条的平均累积长度显著高于20G Procore®针，分别为8.2±4.2mm和4.2±3.8mm（P < 0.01）。未观察到该标准在观察者内和观察者间的变异性。我们的结果表明存在显著差异，22G Acquire®针每次穿刺活检所取组织条的平均累积长度显著更高。这个简单的标准似乎可靠且可重复。
