Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Integrative Marine Ecology Department, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Mar Drugs. 2019 May 7;17(5):269. doi: 10.3390/md17050269.
Over the last decade, genome sequences and other -omics datasets have been produced for a wide range of microalgae, and several others are on the way. Marine microalgae possess distinct and unique metabolic pathways, and can potentially produce specific secondary metabolites with biological activity (e.g., antipredator, allelopathic, antiproliferative, cytotoxic, anticancer, photoprotective, as well as anti-infective and antifouling activities). Because microalgae are very diverse, and adapted to a broad variety of environmental conditions, the chances to find novel and unexplored bioactive metabolites with properties of interest for biotechnological and biomedical applications are high. This review presents a comprehensive overview of the current efforts and of the available solutions to produce, explore and exploit -omics datasets, with the aim of identifying species and strains with the highest potential for the identification of novel marine natural products. In addition, funding efforts for the implementation of marine microalgal -omics resources and future perspectives are presented as well.
在过去的十年中，已经为广泛的微藻产生了基因组序列和其他组学数据集，还有其他一些正在进行中。海洋微藻具有独特的代谢途径，并且可以潜在地产生具有生物活性的特定次生代谢产物（例如，抗捕食者、化感、抗增殖、细胞毒性、抗癌、光保护以及抗感染和防污活性）。由于微藻非常多样化，并且适应了广泛的环境条件，因此发现具有生物技术和生物医学应用价值的新型和未探索的生物活性代谢产物的机会很高。这篇综述全面概述了目前为产生、探索和利用组学数据集所做的努力和可用的解决方案，目的是确定具有鉴定新型海洋天然产物潜力的最高物种和菌株。此外，还介绍了实施海洋微藻组学资源的资金努力和未来展望。
